Topical drug delivery for treatment of fungal infection

Abstract

Topical route of administration is the most convenient route for drug administration. In this route of administration increase the pharmacodynamic and pharmacokinetic parameters. Fluconazole is an antifungal drug which belongs to the class second drug as per BCS. Fluconazole is a triazole derivative. Fluconazole available in the market different formulation tablet, capsules, gels, creams etc. Fluconazole is the broad-spectrum antifungal agent it is inhibits the fungal infections on the superficial layer of the skin. Topical drug delivery system is classified in gels, lotions, creams, ointment, topical powder, pastes, suppositories, paints and plasters etc. Creams are formulated by the oil in water and water in oil emulsion types of cream. This review focus on the comparative study of gel and cream formulation. Creams adhered to the upper layer of the skin and help to cure fungal infections. Skin is the most preferable route for the topical dosage forms and it is upgrade the bioavailability of the drug through, the bypass metabolism.