Preparation and Evaluation of Nanogel Attached Through Methotrexate for Managing Psoriasis

Authors

  • Kuldeep Shukla School of Pharmaceutical Science, Shri Venkateshwara University, Gajraula (UP) -244236 India
  • Bhuwanendra Singh School of Pharmaceutical Science, Shri Venkateshwara University, Gajraula (UP) -244236 India

Keywords:

Psoriasis, Methotrexate, chitosan, Optimization, Nanoparticles

Abstract

There is novel preparation of nanoparticle for targeted delivery of methotrexate. The drug of choice for the treatment of Psoriasis. We find very enchanted result of the prepared formulation that is very high stable and very less toxic as earlier pure methotrexate and our study reveals that the dose reduction and targeted therapy have very great importance in managing psoriasis. The stability was good as we find from the study and nanogel was followed sustained release pattern of the nanogel with good spreadability and intrinsic homogeneity. Moreover, if we discuss about the various parameters performed in the research such as particle size and zeta potential then these both of the tests give the information about better ADME and confirm the delivery potential respectively. Entrapment efficiency is needed to know the exact amount of drug contained or engulfed by the nanoparticle. The current research focused on the nano formulation to treat the Psoriasis for better drug release with less toxicity.

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Published

2020-05-31

How to Cite

Kuldeep Shukla, & Bhuwanendra Singh. (2020). Preparation and Evaluation of Nanogel Attached Through Methotrexate for Managing Psoriasis. World Journal of Pharmaceutical Sciences, 8(6), 102–108. Retrieved from https://wjpsonline.com/index.php/wjps/article/view/168

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Section

Research Article