Analytical and Bio-analytical Methods of Telbivudine: A Review

M. Gnana Chandrika; M. Vamsi Krishna; K. Padmalatha

Analytical and Bio-analytical Methods of Telbivudine: A Review

Authors

M. Gnana Chandrika Department of Pharmaceutical Analysis, Vijaya Institute of Pharmaceutical Sciences for Women, Enikepadu, Vijayawada-521108, Andhra Pradesh, India
M. Vamsi Krishna Department of Pharmaceutical Analysis, Vijaya Institute of Pharmaceutical Sciences for Women, Enikepadu, Vijayawada-521108, Andhra Pradesh, India
K. Padmalatha Vijaya Institute of Pharmaceutical Sciences for Women, Enikepadu, Vijayawada-521108, Andhra Pradesh, India

Keywords:

Telbivudine, Hepatitis B virus, Analytical and bio-analytical methods

Abstract

Telbivudine is a synthetic thymidine nucleoside analog with specific activity against the hepatitis B virus. Telbivudine acts by inhibiting HBV DNA polymerase (reverse transcriptase) by competing with the natural substrate, thymidine 5'–triphosphate. This leads to the chain termination of DNA synthesis, thereby inhibiting viral replication. HPLC and LC-MS/MS methods have been reported for the estimation of telbivudine in bulk drugs, pharmaceutical formulations and biological fluids. In this review we have presented the different analytical and bio-analytical methods reported for the telbivudine.

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Published

2020-07-01

How to Cite

M. Gnana Chandrika, M. Vamsi Krishna, & K. Padmalatha. (2020). Analytical and Bio-analytical Methods of Telbivudine: A Review. World Journal of Pharmaceutical Sciences, 8(7), 12–15. Retrieved from https://wjpsonline.com/index.php/wjps/article/view/176