Effect of Buchanania Lanzan on wound healing potential in diabetic rats

Manimekalai Pichaivel; Krishnaraju Venkatesan; Kalpana Krishnaraju; Saravanan VS; Premalatha Paulsamy; Divya Kuppan

Authors

Manimekalai Pichaivel Professor & Head Department of Pharmacology, SVCP, Tiruchengode, Tamil Nadu, India
Krishnaraju Venkatesan Department of Pharmacology, College of Pharmacy, King Khalid University, Abha, KSA
Kalpana Krishnaraju Erode College of Pharmacy, Veppampalayam, Erode, India
Saravanan VS Erode College of Pharmacy, Veppampalayam, Erode, India
Premalatha Paulsamy King Khalid University, Khamis Mushayit, Asir Province, Saudi Arabia
Divya Kuppan JKK Nataraja College of arts and science, Kumarapalayam, Namakkal District, India

Keywords:

B.lanzan, Wound healing, Diabetic, Dead space wound, Granulation tissue, Streptozotocin

Abstract

The purpose of this study was to assess the wound healing activities of Buchanania lanzan (B.lanzan) fruit extract in streptozotocin-induced diabetes mellitus rat. On each axilla of diabetic rats, dead space incisions were created. For eight days, the rats were randomly assigned to one of three treatment groups (Group I: Normal saline; Group II: Diabetic control; Group III: B.lanzan). Animals were euthanized on day 10, and cotton pellets and granuloma tissues were carefully collected and processed for further estimates. In all, 18 rats were utilized in the experiment.During the trial, the B.lanzan group had a substantial increase in dry and wet tissue weight when compared to the other groups. In addition, as compared to the control, treatment with B.lanzan dramatically enhanced Hydroxyproline, Hexosamines, Hexuronic acid, Tissue protein, and Lysyl oxidase. The increased hydroxyproline levels, as well as other important biochemicals, support the use of B.lanzan for topical wound healing treatment.