Effect of Terminalia Arjuna on dead space wound in diabetic rats

Premalatha Paulsamy; Krishnaraju Venkatesan; Kalpana Krishnaraju; Saravanan VS; Manimekalai Pichaivel; Divya Kuppan

Authors

Premalatha Paulsamy King Khalid University, Khamis Mushayit, Asir Province, Saudi Arabia
Krishnaraju Venkatesan Department of Pharmacology, College of Pharmacy, King Khalid University, Abha, KSA
Kalpana Krishnaraju Department of Pharmacy, Erode College of Pharmacy, Veppampalayam, Erode, India
Saravanan VS Department of Pharmacy, Erode College of Pharmacy, Veppampalayam, Erode, India
Manimekalai Pichaivel Professor & Head Department of Pharmacology, SVCP, Tiruchengode, Tamil Nadu, India
Divya Kuppan JKK Nataraja College of arts and science, Kumarapalayam, Namakkal District, India

Keywords:

T.arjuna, Wound healing, Diabetic, Dead space wound, Granulation tissue, Streptozotocin

Abstract

The effects of Terminalia arjuna (T.arjuna) on the healing of rat cutaneous wounds were studied in diabetic rats utilising an in vivo dead space wound model. On each axilla of diabetic rats, dead space incisions were created. For eight days, the rats were randomly assigned to one of three treatment groups (Group I: Normal saline; Group II: Diabetic control; Group III: B.lanzan). Animals were euthanized on day 10, and cotton pellets and granuloma tissues were carefully collected and processed for further estimates. The tensile strength of the dead space wounds increased statistically significantly, according to the findings. When the hexosamine content of granulation tissue produced from dead space wounds was compared to the control, the hexosamine concentration was found to be higher. In addition, as compared to the control, the levels of hydroxyproline, hexuronic acid, tissue protein, and lysyl oxidase were considerably higher. These findings support the use of T.arjuna, which is primarily composed of tannins, to speed up the healing process. As a result, the current study backs up the plant's wound healing claims in diabetic wounds.