A review on synthetic study and biological activities of tetrahydropyrimidinone derivatives

DOI: https://doi.org/10.54037/WJPS.2021.9909

Authors

  • Ruchita Tale Department of Pharmaceutical Chemistry, Priyadarshini J L College of Pharmacy, Nagpur, India
  • Dinesh Chaple Department of Pharmaceutical Chemistry, Priyadarshini J L College of Pharmacy, Nagpur, India
  • Alpana Asnani Department of Pharmaceutical Chemistry, Priyadarshini J L College of Pharmacy, Nagpur, India
  • Pratyush Kumar Department of Pharmaceutical Chemistry, Priyadarshini J L College of Pharmacy, Nagpur, India
  • Datta Avhad Department of Pharmaceutical Chemistry, Priyadarshini J L College of Pharmacy, Nagpur, India

Keywords:

Drug discovery, 2-thioxo-1, 2, 3, 4-tetrahydropyrimidine, Biginelli reaction, antioxidant activity, antihypertensive activity

Abstract

The process of drug discovery involves the identification, synthesis, characterization, screening, assay and development of new chemical entities that are suitable for medical and pharmaceutical use. 2-thioxo-1, 2, 3, 4-tetrahydropyrimidine (THPM) are heterocyclic compound & represents are markable pharmacological efficient moieties and are with wide range of therapeutic properties. Synthetically they were synthesized using Multi-component reactions like Biginelli reaction or either microwave and conventional methods, having a multiple benefits of the time consuming and get high yield. In this review, we highlight recent developments on THPMs and recently developed as antimicrobial, anticancer, anti- inflammatory, analgesic, antifungal, antibacterial, anti-tubercular, antihypertensive, analgesic, anticonvulsant, antioxidant, etc. given a potent biological and pharmacological activity.

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Published

2021-09-01

How to Cite

Ruchita Tale, Dinesh Chaple, Alpana Asnani, Pratyush Kumar, & Datta Avhad. (2021). A review on synthetic study and biological activities of tetrahydropyrimidinone derivatives: DOI: https://doi.org/10.54037/WJPS.2021.9909. World Journal of Pharmaceutical Sciences, 9(9), 209–222. Retrieved from https://wjpsonline.com/index.php/wjps/article/view/53

Issue

Section

Review Article