Formulate gastroretentive floating bioadhesive drug delivery system of nizatidine by direct compression technique

https://doi.org/10.54037/WJPS.2022.100106

Authors

  • Sravya V Department of Pharmaceutics, Browns College of Pharmacy, Khammam, Telangana, India
  • Suresh Kumar P Department of Pharmaceutics, Browns College of Pharmacy, Khammam, Telangana, India
  • Jagannath Patro V Department of Pharmaceutics, Browns College of Pharmacy, Khammam, Telangana, India
  • Sunitha Ch Department of Pharmaceutics, Browns College of Pharmacy, Khammam, Telangana, India

Keywords:

Nizatidine, Hydroxy propyl methyl cellulose, Gastro-retentive, Floating, Carbopol

Abstract

Nizatidine is a gastroprotective drug with a short biological half-life and narrow absorption window. This study aimed at developing floating tablets of nizatidine using various HPMC viscosity grades, namely K4M, K15M, Carbopol 934P, Sodium alginate and sodium carboxy methyl cellulose. Directly compressed tablets revealed an excellent uniformity in hardness, thickness and weight and nizatidine was evenly distributed within the matrix floating tablets. Buoyancy study revealed the tablets remain buoyant for more than 12 h. Among all the formulations, F12 formulation containing 3:1 ratio of HPMC K15M and Carbopol 934P was found to be promising, which showed a floating lag time less than 5min and floating duration of more than 12 hours. It showed constant drug release up to 12 hours and good bio adhesion strength. All the designed formulations displayed zero order release kinetics and drug release follows non-Fickian diffusion mechanism.

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Published

2022-01-02

How to Cite

Sravya V, Suresh Kumar P, Jagannath Patro V, & Sunitha Ch. (2022). Formulate gastroretentive floating bioadhesive drug delivery system of nizatidine by direct compression technique: https://doi.org/10.54037/WJPS.2022.100106. World Journal of Pharmaceutical Sciences, 10(01), 59–73. Retrieved from http://wjpsonline.com/index.php/wjps/article/view/gastroretentive-floating-bioadhesive-dds-nizatidine

Issue

Section

Research Article