Formulation and in-vitro evaluation of pulsatile drug delivery system for eplerenone

Authors

  • Vandlakonda Suresh Goud Malla Reddy Institute of Pharmaceutical Sciences, Maisammaguda, Hyderabad, Telangana-500014, India
  • GS Sharma Malla Reddy Institute of Pharmaceutical Sciences, Maisammaguda, Hyderabad, Telangana-500014, India
  • B Rajkamal Malla Reddy Institute of Pharmaceutical Sciences, Maisammaguda, Hyderabad, Telangana-500014, India

Keywords:

Eplerenone, Sodium starch glycolate, Ethyl cellulose, HPMC

Abstract

Eplerenone is a steroidal anti-mineralocorticoid of the spirolactone group that is used as an adjunct in the management of chronic heart failure and high blood pressure, particularly for patients with resistant hypertension due to elevated aldosterone. The present work is to develop and evaluation of press coated tablets of Eplerenone by using polymers like Ethyl cellulose, HPMC. From the reproducible results obtained from the executed trails of core and press coated tablets it can be concluded that F6 of core tablet and E2F6 of press coated tablet were maintained lag phase upto 6hrs and brust release was at 7th hr and followed by maximum release at the end of 8th hr, so it is selected as optimized formulations for designing Pulsatile device. Therefore the study proved that coated Eplerenone can be successfully used as a time dependent modified Chronopharmaceutical formulation.

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Published

2020-11-30

How to Cite

Vandlakonda Suresh Goud, GS Sharma, & B Rajkamal. (2020). Formulation and in-vitro evaluation of pulsatile drug delivery system for eplerenone. World Journal of Pharmaceutical Sciences, 8(12), 141–146. Retrieved from https://wjpsonline.com/index.php/wjps/article/view/in-vitro-evaluation-pulsatile-drug-delivery-system-eplerenone

Issue

Section

Research Article