Investigation of transdermal patches of fenugreek seed extract for the treatment of diabetes mellitus
Keywords:Transdermal patch, Fenugreek seed extract, Trigonelline, Diabetes mellitus
The present study reports the Investigation of Transdermal patches of Fenugreek seed extract for the treatment of Diabetes mellitus. Fenugreek seed extract was obtained from the Fenugreek seed (Trigonella foenumgraecum) belongs to the family Leguminosae. Used in the treatment diabetes mellitus, lower blood cholesterol level etc. It contains active constituents like trigonelline, choline etc. which involved in producing the antidiabetic activities and it also contain galactomannans content of the extract was responsible for the skin hydration. Therefore, it is possible that a topical formulation of fenugreek extract could enhance permeation and absorbed mainly at a specific absorption site in the skin. Transdermal patches containing fenugreek extract was formulated and evaluated for various parameters. The drug content show drug release of almost 90% after 6hr. Out of different formulation 2:2 ratio was found to have highest release. The results demonstrate that the controlled release from a transdermal drug delivery system also enhance better therapeutic efficacy, improved patient compliance and side effect associated with conventional drugs can be avoided.
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