Lead Optimization Studies on Novel Quinolones Derivatives as CYP-450 Inhibitor by using In-Silico Modulation

Authors

  • Himanshu Joshi Invertis Institute of Pharmacy, Invertis University, Bareilly-243123, India
  • Ratandeep Chauhan Invertis Institute of Pharmacy, Invertis University, Bareilly-243123, India
  • Pankaj Kumar Shankhdhar Invertis Institute of Pharmacy, Invertis University, Bareilly-243123, India
  • Kalbant Kumar Shri Ram Murti Smarak Institute of Pharmacy, Bareilly-243007, India

Keywords:

In-silico, Quinolone, CYP450 inhibitor

Abstract

The In-silico studies considered as complementary to in vivo and in vitro biological studies are performed by using a computer and are playing increase larger and more important role in drug discovery and development. We describe here in In-silico study of various hypothetical Quinolines and their interactions with CYP450 enzymes by computational methods including chem draw ultra, Avogadro and ochem database software methods. We worked on a chemical reaction scheme of Quinolines and we prepared different 20 Quinolines derivatives. The CYP450 super family of heme enzymes plays an important role in the metabolism of a large number of endogenous and exogenous compounds including most of the drugs currently on the market. Comprehensive studies of the quantum approaches on the quinolines derivatives like QD1, QD8 and QD13 was found to be CYP450 enzymes inhibitors interactions. The quantum approaches by lead optimization will require further studies; the data reported in this work may be helpful guide for medicinal chemist who is working in this area.

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Published

2019-03-03

How to Cite

Himanshu Joshi, Ratandeep Chauhan, Pankaj Kumar Shankhdhar, & Kalbant Kumar. (2019). Lead Optimization Studies on Novel Quinolones Derivatives as CYP-450 Inhibitor by using In-Silico Modulation. World Journal of Pharmaceutical Sciences, 7(3), 177–186. Retrieved from http://wjpsonline.com/index.php/wjps/article/view/lead-optimization-studies-quinolones-cyp-450

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Section

Research Article

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