Review on methods and mechanisms available for producing poly cystic ovary syndrome (PCOS) in animal models: experimental purpose (pre-clinical studies)

https://doi.org/10.54037/WJPS.2022.100118

Authors

  • Shahul Hameed S Student – Bachelor of Pharmacy, Arulmighu Kalasalingam College of Pharmacy, Anand Nagar, Krishnakoil- 626 126, Srivilliputtur, Virudhunagar district, Tamil Nadu
  • Manjuladevi M Student – Bachelor of Pharmacy, Arulmighu Kalasalingam College of Pharmacy, Anand Nagar, Krishnakoil- 626 126, Srivilliputtur, Virudhunagar district, Tamil Nadu
  • Rajakumari S Student – Bachelor of Pharmacy, Arulmighu Kalasalingam College of Pharmacy, Anand Nagar, Krishnakoil- 626 126, Srivilliputtur, Virudhunagar district, Tamil Nadu
  • Athira S. K Student – Bachelor of Pharmacy, Arulmighu Kalasalingam College of Pharmacy, Anand Nagar, Krishnakoil- 626 126, Srivilliputtur, Virudhunagar district, Tamil Nadu
  • Tamiljothi E Professor- Department of Pharmacology, Arulmighu Kalasalingam College of Pharmacy, Anand Nagar, Krishnakoil- 626 126, Srivilliputtur, Virudhunagar district, Tamil Nadu

Keywords:

PCOS, letrazole, Estradiol valerate, Prenatal Androgen, DHEA

Abstract

Poly cystic ovary syndrome (PCOS) is one of the most common endocrine disorder, the cause of PCOS is not accurately understood. So, it’s a challenging task for the scientist/researcher for the discovery of new drugs for the treatment of PCOS. Considering with new drug discovery for treatment of PCOS, that drug should undergo pre-clinical studies using animal models, in animal models PCOS was initially induced and treated with testing drug, most commonly four methods were used for induction. (letrazole induced PCOS, Estradiol valerate induced PCOS, prenatal Androgen induced PCOS, Dehydroepiandrosterone (DHEA) induced PCOS). Among these four methods letrazole induced PCOS method is easy and convenient method.

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Published

2022-01-02

How to Cite

Shahul Hameed S, Manjuladevi M, Rajakumari S, Athira S. K, & Tamiljothi E. (2022). Review on methods and mechanisms available for producing poly cystic ovary syndrome (PCOS) in animal models: experimental purpose (pre-clinical studies): https://doi.org/10.54037/WJPS.2022.100118. World Journal of Pharmaceutical Sciences, 10(01), 155–158. Retrieved from http://wjpsonline.com/index.php/wjps/article/view/mechanisms-producing-pcos-animal-models-review

Issue

Section

Review Article