@article{Pushpam M_Patric Joshua P_Arumugam P_2017, title={Effect of Ocimum sanctum Linn (Tulsi) leaves on pyrexia}, volume={5}, url={https://wjpsonline.com/index.php/wjps/article/view/effect-ocimum-sanctum-tulsi-leaves-pyrexia}, abstractNote={<p><strong><em>Background:</em></strong> Drug therapy of fever with Standard drugs, are always accompanied by side effects which is a well-known factor and the therapy is open to other alternative/adjuvant supplements/ medications with no/minimal side effects. Our traditional “holy herb” <em>Tulsi</em> are   indicated for all reasons and in all the seasons. In view of this, a trial was conducted for their antipyretic activity. <strong><em>Objective</em></strong>: To assess the anti-pyretic property of <em>Ocimum Sanctum Linn fresh (tulsi)</em> <em>leaves</em>, (native) preparation, in experimentally induced acute fever in   animal models. <strong><em>Methodology:</em></strong> Adult <em>Wistar Albino Rats</em> of both sex weighing 125-150gms were randomly divided into 2 groups (n=6); First group were the control subjects (distilled water), and the second were the test group (fresh <em>Tulsi </em>leaves (400mg/kg). After recording the basal temperature, fever was induced by injecting 15% of brewer’s yeast. 18 hrs after giving injection, each rat was fed orally with vehicle and test drug accordingly. Temperature was recorded to all animals at every 30, 60,120 and 180 minutes respectively. <strong><em>Results:</em></strong> There was a significant reduction of fever in <em>Tulsi</em> group whereas the temperature control was not significant statistically in control group. <strong><em>Conclusion:</em></strong> Tulsi may be used as primary drug in the therapy of fever.</p>}, number={4}, journal={World Journal of Pharmaceutical Sciences}, author={Pushpam M and Patric Joshua P and Arumugam P}, year={2017}, month={Mar.}, pages={21–24} }