@article{Emmanuel MODO_Ngozika OKWANDU_Bright DONGO_2015, title={Comparative effects of vitamin C and vitamin E pre-treatment in acute paracetamol induced toxicity on the liver of rats}, volume={3}, url={https://wjpsonline.com/index.php/wjps/article/view/acute-paracetamol-induced-toxicity-liver-rats}, abstractNote={<p>Paracetamol as an analgesic can also cause hepatotoxicity at high doses. This study is aimed at determining which of the two vitamins (Vitamin C or Vitamin E) is more potent in moping out the free radicals produced by paracetamol toxicity. Forty-eight male albino rats were used as my experimental model. The comparative hepatoprotective effect of vitamins C and E against paracetamol-induced toxicity was assessed in these rats. Vitamin C and Vitamin E at prophylactic dosage (80 mg / 2.4 ml, 90 mg / 2.7 ml, 100 mg / 3.0 ml and 110 mg / 3.3 ml respectively) were separately administered orally to the test rats concomitant with induced-paracetamol toxicity. Paracetamol toxicity was observed to increase significantly (P < 0.05) activities of serum ALT, AST, and ALP in male albino rats. Oral administration of prophylactic doses of ascorbic acid and α-tocopherol decreased significantly (P < 0.05) activities of these parameters in male albino rats, compared with the non-treated test rats; but insignificant increase (P ≥ 0.05), compared with the control. Vitamin C and Vitamin E are hepato protective substances although Vitamin E is likely more potent than Vitamin C in moping of free radicals produced.</p>}, number={3}, journal={World Journal of Pharmaceutical Sciences}, author={Emmanuel MODO and Ngozika OKWANDU and Bright DONGO}, year={2015}, month={Mar.}, pages={407–412} }