TY - JOUR AU - Emmanuel MODO, AU - Ngozika OKWANDU, AU - Bright DONGO, PY - 2015/03/05 Y2 - 2024/03/28 TI - Comparative effects of vitamin C and vitamin E pre-treatment in acute paracetamol induced toxicity on the liver of rats JF - World Journal of Pharmaceutical Sciences JA - World J Pharm Sci VL - 3 IS - 3 SE - Research Article DO - UR - https://wjpsonline.com/index.php/wjps/article/view/acute-paracetamol-induced-toxicity-liver-rats SP - 407-412 AB - <p>Paracetamol as an analgesic can also cause hepatotoxicity at high doses. This study is aimed at determining which of the two vitamins (Vitamin C or Vitamin E) is more potent in moping out the free radicals produced by paracetamol toxicity. Forty-eight male albino rats were used as my experimental model. The comparative hepatoprotective effect of vitamins C and E against paracetamol-induced toxicity was assessed in these rats. Vitamin C and Vitamin E at prophylactic dosage (80 mg / 2.4 ml, 90 mg / 2.7 ml, 100 mg / 3.0 ml and 110 mg / 3.3 ml respectively) were separately administered orally to the test rats concomitant with induced-paracetamol toxicity. Paracetamol toxicity was observed to increase significantly (P &lt; 0.05) activities of serum ALT, AST, and ALP in male albino rats. Oral administration of prophylactic doses of ascorbic acid and α-tocopherol decreased significantly (P &lt; 0.05) activities of these parameters in male albino rats, compared with the non-treated test rats; but insignificant increase (P ≥ 0.05), compared with the control. Vitamin C and Vitamin E are hepato protective substances although Vitamin E is likely more potent than Vitamin C in moping of free radicals produced.</p> ER -