World Journal of Pharmaceutical Sciences

A NEW VALIDATED METHOD FOR THE ESTIMATION OF SPARSENTAN IN BULK AND PHARAMCEUTICAL DOSEAGE FORM BY - RPHPLC

2024-05-28T12:06:00+00:00

The stability of innovative drug formulation and the development of appropriate stability-indicating methodologies are top priorities in contemporary pharmaceutical studies. The current work has developed and validated a thorough stability-indicating HPLC-PDA method for the determination of Sparsentan, a developing and novel endothelin and angiotensin II receptor antagonist, to reduce levels of protein in the urine (proteinuria) in patients who have a kidney disease called primary immunoglobulin A nephropathy (IgAN), The stability of Sparsentan was examined under different stress conditions. Sparsentan was found to be susceptible to Acid degradation. effective separation of Sparsentan and its induced degradation products was achieved using isocratic elution mode on Discovery C18 150 x 4.6 mm, 5m maintained at 26.5 °C. The mobile phase used was comprised of 80.0 mm 0.1% OPA buffer (pH 2.8 ± 0.05) and acetonitrile (20 by volume), delivered at flow rate of 1.0 mL/min. The photo diode array signal for Sparsentan was monitored at 245.0 nm over a concentration range of 10–60 μg/mL, it is obvious that the recommended method is precise, dependable, economical, and time-saving. Because of this, it can be used for routine quality assurance and stability testing of Sparsentan in tablet form.

QUANTITATIVE DETERMINATION OF BEXAGLIFLOZIN IN TABLET FORMULATION AND BULK BY USING RP-HPLC

2024-05-28T12:17:09+00:00

A new, accurate and sensitive reversed-phase high-performance liquid chromatography (RP-HPLC) as analytical method for the quantitative determination of Bexagliflozin was developed. For HPLC analysis, Reverse phase Chromotography method with photo diode array detector was chosen. The separation of the analyzed compound was conducted by means of a Discovery® C18 (5 μm particle size, L × I.D. 15 cm × 4.6 mm) analytical column, analyzed drugs were determined within 6.0 min using phosphate buffer (4.2ph_dipotassium hydrogen phosphate 0.01N) in water and Methanol in isocratic elution mode as mobile phase at a flow rate of 1.0 mL/min, Temperature was maintained at 30°C. Optimized wavelength selected was 220.0nm. Retention time of Bexagliflozin was found to be 2.167 min. the method was validated to fulfill International Conference on Harmonization (ICH) requirements and this validation included specificity, linearity, limit of detection (LOD), limit of quantification (LOQ), accuracy, precision, and robustness. The calibration curve was linear over the concentration range from 5 to 30 μg/ml, The accuracy and precision of the method were within the acceptable limit of ±20% at the lower limit of quantitation and ±15% at other concentrations, all results were acceptable and this confirmed that the method is suitable for its intended use in routine quality control and assay of drugs.

FORMULATION AND EVALUATION OF HERBAL BURN CREAM

2024-05-22T06:40:20+00:00

The primary objective of the current study was to develop and assess the burn healing properties of a cream made from herbal plants. Herbal remedies are now widely used for both medical and financial purposes. The burn cream made from herbal plants is more effective than synthetic medications, which can have certain negative side effects. According to this study, aloe vera has anti-inflammatory properties and mint has skin-healing properties. These two herbs work incredibly well together.

SYNTHESIS OF A CHITOSAN BASED HYDRO GEL FROM SCALES OF LABEO ROHITO FOR EFFECTIVE WOUND HEALING

2024-05-22T06:35:31+00:00

The present work illustrates a met hod to synthesize an organic hydro gel that is superior, cheaper, bio-compatible and enables faster wound healing. Chitosan-based hydro gel was synthesized with acetic acid as the solvent medium and glutaraldehyde as the cross linker. The prepared hydro gel was characterized and tested using FTIR (Fourier Transform Infrared Analysis), SEM (scanning electron microscopy), also swelling test, and antibacterial activity was observed. The results of the present study demonstrate that the prepared hydro gel showed antibacterial activity with effective swell ability and structural and surface characteristics. Based on the characterization studies, it is concluded that the synthesized hydro gel had shown better characteristics and can be used as a promising material for wound healing applications.

FORMULATION AND INVITRO EVALUATION OF LURASIDONE PULSATILE DRUG DELIVERY

2024-07-02T11:18:25+00:00

The development of site-specific, pulsatile drug delivery systems (DDS) aims to optimize therapeutic efficacy and minimize side effects by ensuring drug release at a predetermined time and site within the gastrointestinal tract. This study explores the formulation and evaluation of an oral pulsatile drug delivery system utilizing Lurasidone, an atypical antipsychotic agent, as a model drug. Lurasidone is primarily used in the treatment of schizophrenia and bipolar disorder, conditions requiring precise and timely drug release to align with the body's circadian rhythms and symptom fluctuations. The proposed system integrates time-controlled release mechanisms to target drug release at specific segments of the gastrointestinal tract, particularly the colon. This is achieved through the use of a combination of pH-sensitive polymers, enzymatically degradable materials, and chronotherapeutic approaches. The formulation involves a core tablet containing Lurasidone, coated with a series of layers designed to delay drug release until reaching the desired site of action. In vitro dissolution studies and in vivo pharmacokinetic evaluations are conducted to assess the lag time, release profile, and bioavailability of Lurasidone from the pulsatile DDS. The results demonstrate a significant improvement in the synchronization of drug release with the targeted site, achieving a pulsatile release pattern conducive to the management of psychiatric conditions. An insoluble hard gelatin capsule body, filled with a powder blend, and sealed with a hydrogel plug make up the fundamental design. The powder mix including talc, MCC, crospovidone, Lycoat, and Ludiflash as disintegrants, and Lurasidone as the medication was made and tested for flow characteristics using FTIR analysis. The F12 powder mix formulation was chosen for additional pulsatile capsule production based on the findings obtained. To maintain an appropriate lag duration, a hydrogel plug was produced in a 1:1, 1:2, and 2:1 ratio combining hydrophobic polymers such lactose with hydrophilic polymers like HPMC. It was discovered that the percentage of polymers utilized influenced the drug release. The produced formulations were assessed for In vitro release studies, drug content, and weight variance. Lurasidone was found to be released from the pulsincap after a predefined lag time of six hours, according to in vitro release experiments of the pulsatile device. FTIR measurements verified that there was no interaction between the medication and polymers. It was discovered that PC5F12 was an optimal formulation based on conducted in vitro investigations.

CURRENT ASPECTS OF TECHNOLOGY TRANSFER IN PHARMACEUTICAL INDUSTRIES

2024-05-22T06:38:13+00:00

This review article’s goal is to go into great depth on the transfer of technology in the pharmaceutical sector. The piece discusses the importance, reasons, facets of TT, factors affecting the success of TT, classification, models, TT process, and stages that make up the procedure. This effort to comprehend the issues associated with TT discusses the documentation portion of the technology transfer. The transfer could be deemed effective if both the receiving and transferring units are successful in using the technology for commercial gain. Understanding a process's capacity to effectively forecast how a process will perform in the future is a prerequisite for the success of any given technology transfer. A successful technology transfer requires three main factors into account: the strategy, the people involved, and the procedure. Technology transfer involves ongoing information flow between the parties to continue product manufacture, not just one-off actions taken by the transferring party in the direction of the transferred party.

CASSIA AURICULATA: A COMPREHENSIVE REVIEW OF THE NUTRITIONAL, EXPLORING SERUM LIPID PROFILE IN PATIENTS DIAGNOSED WITH MYOCARDIAL INFARCTION AT HAYAT ABAD MEDICAL COMPLEX PESHAWAR

2024-05-22T06:32:03+00:00

Myocardial Infarction (MI) is a critical medical emergency necessitating early diagnosis for effective patient management and complication prevention. Blood biomarkers serve a pivotal role in predicting and preventing MI. This study, conducted in the cardiology department at Hayatabad Medical Complex, Peshawar, focused on investigating the serum lipid profile in MI patients. Using a non-probability convenient sampling technique, 109 diagnosed MI patients were recruited, and 3 to 5 ml blood samples were aseptically collected and processed at the tertiary healthcare hospital. The collected samples were centrifuged to obtain serum, and routine biochemistry analysis using a COBAS analyzer was employed to measure serum lipid levels, including cholesterol, triglyceride, high-density lipoprotein cholesterol (HDL), low-density lipoprotein cholesterol (LDL-C), and very low-density lipoprotein (VLDL-C).Statistical analysis revealed a male predominance (63.3% vs. 36.7%), with the age group of 51 to 60 years being commonly affected (29%). Dyslipidemia analysis indicated a prevalent abnormal elevation of VLDL-C in 57.8% of MI patients, accompanied by hypertriglyceridemia in 33.9%. Additionally, 46.8% of patients exhibited a significant decrease in HDL levels, while 11.9% showed elevated LDL cholesterol and 2.8% presented with hypercholesterolemia. In conclusion, this study highlights that abnormal increases in blood lipid levels contribute to the predisposition of patients to myocardial infarction. The identification of elevated blood lipids underscores the need for immediate management to mitigate further complications in MI patients

CRITICAL REVIEW OF TRANSCUTANEOUS ELECTRICAL NERVE STIMULATION (TENS)

2024-05-22T06:21:45+00:00

Between the different Modalities for pain management Transcutaneous Electrical Nerve Stimulation (TENS) is one of them, which is safe, very effective, painless, transcutaneous and cost-effective modality. It is mostly used in Arthritis and different type of other pains such as joint pain, neck, lower and upper back pain, Fibromyalgia, Muscle pain and also in Neuropathic pain etc. In this paper description of TENS and its mode of action is elaborated.