World Journal of Pharmaceutical Sciences https://wjpsonline.com/index.php/wjps <p><strong>The World Journal of Pharmaceutical Sciences (WJPS; Print ISSN: 2321-3310; Online </strong><strong>ISSN: 2321-3086)</strong> is an international, peer-reviewed monthly open-access journal published by Atom and Cell Publishers. The journal welcomes original research articles, review articles, short communications, mini-reviews, case reports, letter to the editor, guest editorial or commentaries and editorials of all aspects of pharmacy and pharmaceutical sciences.</p> <p><strong>Why publish with WJPS</strong></p> <p><strong>Impact Factor: 1.318</strong></p> <p><strong>Crossref DOI Assigned: 10.54037/WJPS</strong></p> <p><strong>Quick Quality Review: </strong>The journal has strong international team of editors and reviewers. Constructive reviews from renowned scientist and researcher at all editorial levels.</p> <p><strong>Rapid Decision and Publication:</strong> We guarantee a review of your manuscript by a panel of qualified experts within 15 days of submission. Authors that need a faster decision can request Fast Track review and get a response in 3-5 business days.</p> <p><strong>Indexing</strong>: Google Scholars; Advanced Science Index; Chemical Abstracts Service; Cosmos Impact Factor; CiteFactor; Directory of Research Journals Indexing; Eurasian Scientific Journal Index; Geneva Foundation for Medical Education and Research; Global Impact Factor; Index Copernicus; InfoBase Index; International Impact Factor Services; International Scientific Indexing; Open Academic Journals Index; Polish Scholarly Bibliography; Scholarsteer</p> <p><strong>Low Publication Fees:</strong> Comparable journals charge a huge sum for each accepted manuscript. WJPS only charges the fees necessary to recoup costs associated with running the journal.</p> <p>You may submit manuscripts online through following link <a href="https://wjpsonline.com/index.php/wjps/about/submissions" target="_blank" rel="noopener">https://wjpsonline.com/index.php/wjps/about/submissions</a> or as an email attachment to the following mail: editor.wjps@gmail.com</p> en-US editor@wjpsonline.com (Editor-in-Chief) editor@wjpsonline.com (World Journal of Pharmaceutical Sciences) Wed, 20 Nov 2024 00:00:00 +0000 OJS 3.3.0.7 http://blogs.law.harvard.edu/tech/rss 60 FORMULATION AND INVITRO CHARACTERIZATION OF MACITENTAN SOLID DISPERSION TO FAST DISINTEGRATING TABLETS https://wjpsonline.com/index.php/wjps/article/view/1678 <p>Macitentan is an endothelin receptor antagonist utilized for the management of pulmonary arterial hypertension to impede disease development.It is a BCS Class II medication. To enhance the biological efficacy of Macitentan, a solid dispersion was formed into an oral disintegrating tablet utilizing PEG 6000, Xylitol, and PVP K30. Solid dispersions of Macitentan were created using several carriers in distinct ratios of drug to carrier (1:1, 1:2, 1:3, and 1:4). The outcomes of the generated solid dispersions of Macitentan using the solvent evaporation method were examined, including solubility, melting point determination, drug content uniformity, and in vitro dissolution investigations.Characterization in the solid state was conducted using several analytical methods, including FT-IR investigations.Ultimately, while evaluating all formulations, formulation (F12) including Macitentan and PVP K30 in a 1:4 ratio demonstrated superior outcomes using the solvent evaporation technique after 60 minutes, achieving maximal drug release; hence, it was designated as the optimal formulation.Fast dissolving tablets were produced from the optimal formulation utilizing several disintegrants at varied concentrations.The pre-compression and post-compression parameters were analyzed, and the findings were presented. All findings fall within permissible limits.The in vitro drug release of the prepared tablets was conducted using a 6.8 pH phosphate buffer. The F12T12 formulation with 50mg of Cropovidone exhibits a drug release of 99.74±1.48% within 20 minutes. The improved formulation adheres to first-order release kinetics.</p> T.Mohitha, Copyright (c) 2024 T.Mohitha, https://creativecommons.org/licenses/by-nc-sa/4.0 https://wjpsonline.com/index.php/wjps/article/view/1678 Wed, 20 Nov 2024 00:00:00 +0000 FORMULATION AND EVALUATION OF RILPIVIRINE NANOSUSPENSION BY NANO PRECIPITATION METHOD https://wjpsonline.com/index.php/wjps/article/view/1692 <p>The aim of the present work is to develop oral Nanosuspension of Rilpivirine by Nano Precipitation method using various Stabilizers &amp; Surfactant such as β-cyclodextrin, Soluplus, Poloxamer 407, Polyvinyl alcohol, Sodium lauryl sulfate, Polysorbate 80 Various formulation as well as process parameters were optimized in order to achieve desirable size and saturation solubility. Characterization of the prepared Nanosuspension was done with respect to Drug Content, Percentage yield, Entrapment efficiency, Viscosity, Sedimentation volume, Scanning electron microscopy, Particle’s size, zeta potential, dissolution rate, in-vitro dissolution study. Zeta potential value for the optimized formulation (NS12) was found to -4.49 mv which was found to be within the acceptable limits. Average particle size of Nano suspension of optimized formulations (NS12) which is in ratio with Poloxamer 407 was found to be 500.4 nm. From the In vitro studies we can say that formulation NS12 shows best drug release of 98.42±1.27% within 30 minutes whereas all the other formulations didn’t release the drug. The drug release from the Nanosuspension was explained by the using mathematical model equations such as zero order, first order, and equation methods. Based on the regression values it was concluded that the optimized formulation NS12 follows first order kinetics with super case-II transport mechanism and the stability studies shows that the formulation was stability upto 3Months of time period.</p> A. Vivek Pavan Kumar Copyright (c) 2024 A. Vivek Pavan Kumar https://creativecommons.org/licenses/by-nc-sa/4.0 https://wjpsonline.com/index.php/wjps/article/view/1692 Fri, 13 Dec 2024 00:00:00 +0000 FORMULATION AND EVALUATION CARBAMAZEPINE BILAYER TABLET https://wjpsonline.com/index.php/wjps/article/view/1675 <p>Gastro-retentive medication delivery methods are extensively utilized to extend the retention of dose forms in the stomach. The floating bilayer tablet formulation provides sustained drug release and extended stomach retention, in addition to the benefits of a liquid oral dose form. This study aimed to formulate and assess floating bilayer tablets of Carbamazepine utilizing various polymers, including Lycoat and Crospovidone as superdisintegrants, and Xanthan Gum and Carbopol 934P as extended-release polymers, alongside additional substances such as Magnesium stearate, Sodium bicarbonate, citric acid, Talc, PVP K30, MCC, and Lactose. The fabricated bilayered tablets were assessed for hardness, weight fluctuation, thickness, friability, drug content homogeneity, and in vitro dissolution experiments. F6(IR) and F12(SR) were identified as the optimum formulations based on many assessment factors. The aforementioned buoyancy measurements indicate that F12 exhibits a greater total floating time compared to the other formulations. Formulations F6 (IR) and F12 (SR) exhibited the highest drug release within the specified timeframe. All formulations underwent drug release kinetics tests, including zero order, first order, Higuchi matrix, and Peppas model equations. The sustained release (SR) formulations exhibited zero order release with a super case II transport mechanism.</p> G.Kumari Copyright (c) 2024 G.Kumari https://creativecommons.org/licenses/by-nc-sa/4.0 https://wjpsonline.com/index.php/wjps/article/view/1675 Wed, 20 Nov 2024 00:00:00 +0000 FORMULATION AND IN VITRO EVALUATION OF SELEXIPAG CONTROLLED RELEASE TABLETS https://wjpsonline.com/index.php/wjps/article/view/1686 <p>Selexipag has a short biological half-life of 0.8-2.5 hours and having less bioavailability which necessitates multiple daily dosing. Hence the present study was aimed to develop a controlled release formulation of Selexipag to reduce the dose related side effects and to reduce the dosage regimen. The present research project aimed to develop a Control release oral formulation of hypertension drug Selexipag, the present research comprising Selexipag used for the symptomatic relief of pulmonary arterial hypertension. Polymers like HPMC K15 M, Carbopol 940, Pectin and Gellan Gum were used for controlling the drug release, and the polymers are mixed in a predetermined ratio. Totally 12 formulations were prepared and evaluated for pre-compression and post-compression parameters, and all the results were found to be within the limits. From the drug and excipients compatibility studies (FT-IR) it was confirmed that the drug and excipients used weren’t have any interactions. The in vitro dissolution studies revealed that the F9 formulation containing 6mg of Pectin controls the drug release up to 12 hours. So Pectin containing F9 formulation was considered to be suitable for the formulation of Selexipag controlled release tablet and the drug release kinetics revealed that the F9 formulation shows zero order kinetics with super case- II transport mechanism.</p> Surisetty Sridevi Copyright (c) 2024 Surisetty Sridevi https://creativecommons.org/licenses/by-nc-sa/4.0 https://wjpsonline.com/index.php/wjps/article/view/1686 Thu, 05 Dec 2024 00:00:00 +0000 QUALITY EVALUATION OF NYCTANTHES ARBOR-TRISTIS EXTRACTS BY UV-VIS SPECTROSCOPY AND HIGH-PERFORMANCE THIN-LAYER CHROMATOGRAPHY TECHNIQUES https://wjpsonline.com/index.php/wjps/article/view/1669 <p>Nyctanthes Arbor-tristis is one of the most useful medicinal plants in India. Each part of the plant has some important medicinal value and is thus commercially exploitable. The popular medicinal use of this plant is anti-inflammatory, anti-pyretic, anti-viral, anti-bacterial, anti-allergic and diabetes control and it is used as several diseases. The present research is to isolate plant pigments by different extraction techniques and to focus on the identification and determination of the purity, quality, quantity by using UV-Visible spectroscopy and High performance thin-layer chromatography technique. From the results obtained by the above analytical techniques it is observed that Soxhlet extraction technique showed better results in HPTLC when compared to masceration technique.</p> B. Sandhya Rani Copyright (c) 2024 B. Sandhya Rani https://creativecommons.org/licenses/by-nc-sa/4.0 https://wjpsonline.com/index.php/wjps/article/view/1669 Wed, 20 Nov 2024 00:00:00 +0000 FORMULATION AND IN VITRO EVALUATION OF EZOGABINE ORAL THIN FILMS https://wjpsonline.com/index.php/wjps/article/view/1684 <p>Fast dissolving drug delivery system offers a solution for those patients having difficulty in swallowing tablets/capsules. The present research work is to develop oral thin films of Ezogabine by using solvent casting method. Oral thin films were developed by using various super disintegrants like Lycoat and Ludiflash in different concentrations with Gelatin, Poly vinyl alcohol as a film forming agents. The prepared formulations of films were evaluated for film thickness measurement, folding endurance study, in-vitro disintegration time, in-vitro drug release pattern (in pH 6.8 phosphate buffer). Drug content, and drug-polymers interaction study (IR spectroscopy). Among all formulations, the formulation (F12) prepared by 450mg of Lycoat show good drug release (99.37±1.45%).</p> Surisetty Sridevi Copyright (c) 2024 Surisetty Sridevi https://creativecommons.org/licenses/by-nc-sa/4.0 https://wjpsonline.com/index.php/wjps/article/view/1684 Thu, 05 Dec 2024 00:00:00 +0000 FORMULATION AND INVITRO EVALUATION OF ROFLUMILAST ORALLY DISINTEGRATING TABLET https://wjpsonline.com/index.php/wjps/article/view/1681 <p>An Orally disintegrating tablet disperses readily in saliva and the drug is available in solution or suspension form for the immediate absorption and resulting in rapid onset of action. In the present research work Roflumilast Oral disintegrating tablet were prepared by Direct Compression Technique using varying concentrations of Croscarmellose Sodium, Crospovidone and Ludiflash as super disintegrants. The formulations prepared were evaluated for precompression &amp; post compression parameters. Form the drug excipient compatibility studies we observe that there are no interactions between the pure drug (Roflumilast) and optimized formulation (Roflumilast+ excipients) which indicates there are no physical changes. Post compression parameters was found to be within the limits. Among the formulation prepared the tablet containing 2.5 mg concentration of Ludiflash shows 99.85±1.46% of the drug release within 30 min &amp; follows first order kinetics. The overall result indicated that the formulation F12 containing Ludiflash is better and fulfilling of the needs of the Orally disintegrating tablet.</p> V Naga Keerthi Priya Copyright (c) 2024 V Naga Keerthi Priya https://creativecommons.org/licenses/by-nc-sa/4.0 https://wjpsonline.com/index.php/wjps/article/view/1681 Fri, 22 Nov 2024 00:00:00 +0000 PREPARATION AND EVALUATION OF SAFINAMIDE ORAL THIN FILMS https://wjpsonline.com/index.php/wjps/article/view/1676 <p>A fast-dissolving medicine delivery system provides a solution for people who experience trouble swallowing pills or capsules. This research aims to generate oral thin films of Safinamide via the solvent casting process. Oral thin films were made utilizing several super disintegrants, such as lycoat and crospovidone, in varying ratios alongside gelatin and polyvinyl alcohol as film-forming agents. The formulated films were assessed for film thickness, folding endurance, in-vitro disintegration time, and in-vitro drug release profile in pH 6.8 phosphate buffer. Investigation of drug content and drug-polymer interactions using infrared spectroscopy. Among all formulations, formulation F12, made with 450 mg of crospovidone, exhibited favorable drug release (99.34±1.25%).</p> K.Latha Sri Copyright (c) 2024 K.Latha Sri https://creativecommons.org/licenses/by-nc-sa/4.0 https://wjpsonline.com/index.php/wjps/article/view/1676 Wed, 20 Nov 2024 00:00:00 +0000 FORMULATION AND IN VITRO EVALUATION OF ROFLUMILAST PULSATILE DRUG DELIVERY https://wjpsonline.com/index.php/wjps/article/view/1687 <p>The purpose of the present study was to design and evaluate an Oral, site specific, Pulsatile drug delivery system containing Roflumilast as a model drug, which can be time dependent manner, to modulate the drug level in synchrony is a member of the drug class known as statins It is used for lowering cholesterol based on chrono pharmaceutical considerations. The basic design consists of an insoluble hard gelatin capsule body, filled with powder blend and sealed with a hydrogel plug. The powder blend containing Roflumilast, Crospovidone, Lycoat, Croscarmellose sodium, MCC and talc was prepared and evaluated for flow properties and FTIR studies. From the obtained results, F12 powder blend formulation was selected for further fabrication of pulsatile capsules. Hydrogel plug was formulated in a lone and in combination of hydrophobic polymer like lactose with hydrophilic polymers like HPMC K15M in 1:1, 2:1, and 1:2 ratios to maintain a suitable lag period and it was found that the drug release was controlled by the proportion of polymers used. The prepared formulations were evaluated for drug content, weight variation and In vitro release studies. FTIR studies confirmed that there was no interaction between drug and polymers and In vitro release studies of pulsatile device revealed that increasing hydrophilic polymer content resulted in delayed release of Roflumilast from the pulsincap after a predetermined lag time of 6hrs. Based on in vitro studies performed, PC4F12 was found to be optimized formulation.</p> K. Neelima Devi, Copyright (c) 2024 K. Neelima Devi, https://creativecommons.org/licenses/by-nc-sa/4.0 https://wjpsonline.com/index.php/wjps/article/view/1687 Thu, 05 Dec 2024 00:00:00 +0000 PREPARATION AND EVALUATION OF LESINURAD NANOSPONGES BY USING SOLVENT EVAPORATION METHOD https://wjpsonline.com/index.php/wjps/article/view/1685 <p>In this study Lesinurad Nanosponges were prepared by the solvent evaporation technique. The Nanosponges formulations were prepared by solvent evaporation method employing HPMC K4, Carbopol 934, Sodium Alginate rate retarding polymers using PVA as a co polymer. The compatibility of the drug with formulation components was established by Fourier Transform Infra-Red (FTIR) spectroscopy. The surface morphology, percentage yield, and drug entrapment efficiency of Nanosponges were examined. Shape and surface morphology of the Nano sponges were examined using scanning electron microscopy. Scanning electron microscopy revealed the porous, spherical nature of the Nanosponges. SEM photographs revealed the spherical nature of the Nano sponges in all variations; however, at higher ratios, drug crystals were observed on the nano sponge surface. Increase in the drug/polymer ratio which is in increasing order due to the increase in the concentration of polymer but after certain concentration it was observed that as the ratio of drug to polymer was increased, the particle size decreased. The particle size was found in the range of 500 to 680 nm. The entrapment efficiency of different formulations was found in the range of 57.16±1.35% to 78.12±1.33%. The in vitro release studies revealed that the formulation with higher concentration of penetration enhancer showed greater drug release.</p> Dr. D.Nirmala Copyright (c) 2024 Dr. D.Nirmala https://creativecommons.org/licenses/by-nc-sa/4.0 https://wjpsonline.com/index.php/wjps/article/view/1685 Thu, 05 Dec 2024 00:00:00 +0000 ADVANCEMENTS IN THE TREATMENT OF LIVER DISORDERS USING RESEALED ERYTHROCYTES https://wjpsonline.com/index.php/wjps/article/view/1670 <p>Red Blood Cells (RBCs) have distinct qualities including biocompatibility, biodegradability and the ability to release drugs selectively are becoming a viable drug delivery platform these days. The reversible opening of erythrocyte membranes made feasible by recent developments in nanopore technology permits efficient loading and encapsulation of therapeutic drugs. This strategy has the potential to transform both therapeutic and diagnostic applications to be flexible and targeted drug administration. Since resealed erythrocytes can accurately deliver medications while minimizing side effects, they show great potential in both passive and active targeted applications. Erythrocytes also can flex through capillaries and their biconcave form improves their effectiveness as drug transporters. Numerous techniques have been developed for encapsulating pharmaceuticals with erythrocytes, such as electro-encapsulation, hypotonic dilution, and hypotonic haemolysis. Each of these approaches has unique benefits with controlled release and drug loading efficiency. The use of erythrocytes in drug delivery has significant advantages over other factors, such as potential alterations to erythrocyte physiology and the reticuloendothelial system (RES) rapid clearance. In addition, Resealed erythrocytes have demonstrated exceptional potential in delivering antineoplastic medicines, targeting hepatic tumours, and providing enhanced pharmacokinetics in treating liver problems. These carriers may become widely used in therapeutic settings, especially for the facilitated delivery of hormones, steroids, and biopharmaceuticals. The future prospects of erythrocyte-based drug delivery systems as an innovative and attainable strategy in modern medicine are highlighted in this paper.</p> Sincy Sebastian Copyright (c) 2024 Sincy Sebastian https://creativecommons.org/licenses/by-nc-sa/4.0 https://wjpsonline.com/index.php/wjps/article/view/1670 Wed, 20 Nov 2024 00:00:00 +0000 ROLE OF NANOPARTICLES IN THE TREATMENT OF CANCER: A REVIEW https://wjpsonline.com/index.php/wjps/article/view/1666 <p>One of the wide variety of diseases known as cancer is characterized by the unchecked growth of abnormal cells that can enter, destroy, and spread throughout healthy human tissue. An unusual lump, unusual bleeding, chronic cough or breathing difficulties, and weight changes, including unintentional gain or loss, are some of the main signs and symptoms of cancer. Currently, traditional cancer treatments are confined to surgery, radiation, immuno, targeted, and chemotherapy, all of which have the potential to be harmful. However, these conventional anticancer treatments, are challenged by drug resistance, severity, and side effects. To combat this, nanotechnology has been the subject of much research and application in the treatment of cancer. This is because nanotechnology possesses inherent anti-cancer properties owing to its antioxidant action, which also inhibits the formation of tumors. When it comes to treating cancer, nanoparticle-based drug delivery offers several benefits over traditional drug delivery, such as improved stability and biocompatibility, higher permeability and retention effect, and precise targeting. Many anti-cancer drugs, such as 5-fluorouracil, methotrexate, Doxil (doxorubicin), and Abraxane (paclitaxel), have been effectively manufactured using nanomaterials. This study summarizes current developments in the field of cancer treatment and addresses the many kinds of nanoparticles, their benefits, and their targeting mechanisms.</p> Rama Devi Korni Copyright (c) 2024 Rama Devi Korni https://creativecommons.org/licenses/by-nc-sa/4.0 https://wjpsonline.com/index.php/wjps/article/view/1666 Wed, 20 Nov 2024 00:00:00 +0000 STUDY OF THE FREE RADICAL SCAVENGING ACTIVITY OF EUPHORBIA HIRTA https://wjpsonline.com/index.php/wjps/article/view/1683 <p>The analysis of the phytochemical composition of Euphorbia hirta identified a range of compounds, including saponins, polyphenols, flavonoids, tannins, terpenoids, coumarins, and cardiac glycosides. Quantitative assessments showed that the methanolic extract from the roots is particularly high in phenolic compounds, measuring 128.45 ± 5.1 μg GAE / mg of extract. In contrast, the methanol extract from the stems had the highest concentration of flavonoids, at 36.11 ± 0.45 μg QE / mg of extract. The antioxidant capacity of the polar extracts was assessed using the DPPHº method, revealing that the root methanol extract exhibited significant antioxidant activity, with an IC50 value of 07.04 ± 0.14 μg / ml. Furthermore, a correlation was observed between the levels of polyphenols and the presence of phenolic compounds.</p> NADIR EL Mostafa Copyright (c) 2024 NADIR EL Mostafa https://creativecommons.org/licenses/by-nc-sa/4.0 https://wjpsonline.com/index.php/wjps/article/view/1683 Thu, 05 Dec 2024 00:00:00 +0000