Comparative effects of vitamin C and vitamin E pre-treatment in acute paracetamol induced toxicity on the liver of rats

Authors

  • Emmanuel MODO Department of Biochemistry, Madonna University
  • Ngozika OKWANDU Biochemistry laboratories, Simon Fraser University (SFU)
  • Bright DONGO Department of Biochemistry, University of Calabar, Nigeria

Keywords:

Paracetamol induced toxicity, Vitamin C, Vitamin E, Liver function tests; Rats

Abstract

Paracetamol as an analgesic can also cause hepatotoxicity at high doses. This study is aimed at determining which of the two vitamins (Vitamin C or Vitamin E) is more potent in moping out the free radicals produced by paracetamol toxicity. Forty-eight male albino rats were used as my experimental model. The comparative hepatoprotective effect of vitamins C and E against paracetamol-induced toxicity was assessed in these rats. Vitamin C and Vitamin E at prophylactic dosage (80 mg / 2.4 ml, 90 mg / 2.7 ml, 100 mg / 3.0 ml and 110 mg / 3.3 ml respectively) were separately administered orally to the test rats concomitant with induced-paracetamol toxicity. Paracetamol toxicity was observed to increase significantly (P < 0.05) activities of serum ALT, AST, and ALP in male albino rats. Oral administration of prophylactic doses of ascorbic acid and α-tocopherol decreased significantly (P < 0.05) activities of these parameters in male albino rats, compared with the non-treated test rats; but insignificant increase (P ≥ 0.05), compared with the control. Vitamin C and Vitamin E are hepato protective substances although Vitamin E is likely more potent than Vitamin C in moping of free radicals produced.

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Published

2015-03-05

How to Cite

Emmanuel MODO, Ngozika OKWANDU, & Bright DONGO. (2015). Comparative effects of vitamin C and vitamin E pre-treatment in acute paracetamol induced toxicity on the liver of rats. World Journal of Pharmaceutical Sciences, 3(3), 407–412. Retrieved from https://wjpsonline.com/index.php/wjps/article/view/acute-paracetamol-induced-toxicity-liver-rats

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Section

Research Article

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