Study of the Anti-Anxiety Properties of the Phaseollidin, An Isoflavonoid Isolated from Erythrina droogmansiana (Leguminosae)

Talla Emmanuel; Hadidjatou Dairou; Njapdounke Jacqueline; Nkantchoua Gisèle; Yaya Gbaweng Abel Joël; Ngah Esther; Ngo Bum Elisabeth; Mbafor Tanyi Joseph

Authors

Talla Emmanuel Department of Chemistry, Faculty of Science, University of Ngaoundere, POBOX 454, Ngaoundere, Cameroon
Hadidjatou Dairou Département of Biological Science, Faculty of Sciences, University of Ngaoundere, POBOX 454, Ngaoundere, Cameroon
Njapdounke Jacqueline Département of Biological Science, Faculty of Sciences, University of Ngaoundere, POBOX 454, Ngaoundere, Cameroon
Nkantchoua Gisèle Département of Biological Science, Faculty of Sciences, University of Ngaoundere, POBOX 454, Ngaoundere, Cameroon
Yaya Gbaweng Abel Joël Institute of Medical Research and Medicinal plants Studies (IMPM), POBOX 6163, Yaounde, Cameroon
Ngah Esther Department of Applied Chemistry, National School of Sciences Agribusiness, PO Box 454, Ngaoundere, Cameroon
Ngo Bum Elisabeth Département of Biological Science, Faculty of Sciences, University of Ngaoundere, POBOX 454, Ngaoundere, Cameroon
Mbafor Tanyi Joseph Department of Organic Chemistry, Faculty of Science, University of Yaounde 1, POBOX 812, Yaounde, Cameroon

Keywords:

phaseollidin, Erythrina droogmansiana, Anxiety

Abstract

The anti-anxiety properties of the phaseollidin, isoflavonoid isolated from Erythrina droogmansiana, were studied in the white mice. Various experimental models (Elevated Plus-Maze, Open-Field, Hole-Board, Hyperthermia Induced Stress), were used to highlight these properties. The results showed that the phaseollidin involved a significant increase of the time spent in the open arms of the raised labyrinth in cross, with 97.8 ± 21.64 seconds for a dose of 50 mg/kg and 115.4 ± 34.03 seconds for the dose 25 mg/kg. These results thus testify to the fall of the aversion of the rodents for enlightened spaces. In the tests of the hole-board and open-field, used to evaluate the exploration and locomotion activities of mice, the results showed a significant increase of the locomotion (crossing) with 42.2 ± 10.30 for the dose 25 mg/kg and 60 ± 9.05 for the dose 100 mg/kg of the phaseollidin. The doses 25 mg/kg and 100 mg/kg of the phaseollidin also showed a significant increase of “rearing”. These results show that the phaseollidin has anti-anxiety properties.