Anti-diarrheal and antioxidant activity of methanolic leaf extract of Glycosmis pentaphylla Retz.

Abstract

The aim of the present study was designed to evaluate the antidiarrheal and antioxidant effects methanolic extract of Glycosmis pentaphylla. The methanolic extract of G. pentaphylla showed significant reduction in diarrhea frequencies which were 26.99% and 57.67% at doses 200mg/kg and 400mg/kg b.w. respectively compared to loperamide 61.59%. In antioxidant activity, the ranges of total phenolic content of different partitionates were from 0.94 to 3.54 mg of GAE/gm, where the amount of phenolic content decreased in the order PESF (3.54mg)>DCMSF (2.07mg)>AOSF (1.44mg)>MESF (1.33mg)>CSF (0.94mg). Compare to BHT (5.6μg/ml) the IC₅₀ value was significant for the PESF (6.82μg/ml), while AQSF, CSF, DCM and MESF were 7.22μg/ml, 8.0μg/ml, 19.88μg/ml and 60.27μg/ml respectively. It is found that the leaf of G. pentaphylla showed promising antidiarrheal and antioxidant properties and further study is required to ascertain its use in ethno medicine.