Anti-inflammatory and anti-oxidant activity of Dialium dinklagei Harms. (Leguminosae)
Keywords:Oedema, DPPH radical, Carrageenan, Total antioxidant capacity, phytochemicals
Dialium dinklagei is a plant used in the management of pain, arthritis, rheumatism, pulmonary diseases and as a laxative in Ghanaian folklore medicine. However, there is no scientific validation of these pharmacological activities. Therefore, in this research, the anti-oedematogenic and antioxidant activity of a hydro-ethanolic extract of D. dinklagei was evaluated. In vivo anti-inflammatory activity was done by the carrageenan induced oedema in 7 days old chicks. The antioxidant activity was investigated in vitro by the DPPH radical scavenging and phosphomolybdenum total antioxidant capacity assays. D. dinklagei exhibited a dose-dependent anti-inflammatory activity with ED50 of 10.6 mg/kg body weight compared to diclofenac sodium (ED50 = 4.03 mg/kg body weight). It showed considerable antiradical activity (EC50 = 39.6) and a total antioxidant capacity of 581.58 mg of vitamin C per gram of extract. The phytochemicals tannins, alkaloids and terpenoids present in the plant could be responsible for its anti-inflammatory and antioxidant effects. Thus, the present study has given scientific credence to the use of D. dinklagei in ethnomedicine for the management of painful inflammatory conditions.
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