Anticancer activity of methanol extract of Jania Rubens Linn. Against Ehrlich as-cites carcinoma induced Balb/C Mice

Abstract

Cancer is a malignant disease that is characterized by rapid and uncontrolled formation of abnormal cells which may mass together to form a growth or tumor or proliferate throughout the body. Next to heart disease cancer is a major killer of mankind. Present study aims at a preliminary phytochemical screening and anticancer evaluation of methanolic extract of Jania Rubens against Ehrlich Ascites Carcinoma in animal model. The alga Jania Rubens Linn was collected manually at the Devgad Island, near Karwar of the Arabian Sea during May. The powdered sample of alga was subjected to methanol extraction (maceration). The methanolic extract of Jania Rubens given orally to mice at the dose of 250 and 500 mg/kg body weight for 14 days caused significant (p< 0.001) reduction in body weight, packed cell volume and when compared to the mice of the EAC control group. All the values were expressed as mean ± SEM. Means of treated groups were compared with those of control group using one-way analysis of variance (ANOVA) followed by Turkey’s test, control group is compared with normal group using Student’s t test. The Methanol extract of Jania Rubens (250,500 mg/kg) has been showed significant anticancer activity as compared to standard cyclophosphamide in EAC induced cancer model.