Comparative antimicrobial activity of pogostemon cablin (patchouli) essential oil (PEO) and conventional antimicrobials against clinically important microbes

Authors

  • Bhoj Raj Singh Division of Epidemiology, ICAR-Indian Veterinary Research Institute, Izatnagar-243 122, India
  • Dharmendra Kumar Sinha Division of Epidemiology, ICAR-Indian Veterinary Research Institute, Izatnagar-243 122, India
  • Vinodh Kumar O.R Division of Epidemiology, ICAR-Indian Veterinary Research Institute, Izatnagar-243 122, India
  • Abhijit M. Pawde Division of Surgery, ICAR-Indian Veterinary Research Institute, Izatnagar-243 122, India
  • Ujjwal Kumar D.E Division of Medicine, ICAR-Indian Veterinary Research Institute, Izatnagar-243 122, India
  • Vinod Kumar Gupta Division of Medicine, ICAR-Indian Veterinary Research Institute, Izatnagar-243 122, India

Keywords:

Herbal antimicrobials, ESKAPE pathogens, Enterobacter, Escherichia coli, Bacillus, Staphylococcus, Streptococcus, Pseudomonas, Acinetobacter, Salmonella, Aeromonas

Abstract

Pogostemon cablin (patchouli), an important herb with multiple uses, has antimicrobial activity in its infusions, extracts and oil. Patchouli essential oil (PEO), an important perfumery ingredient has till date been tested for its potential antimicrobial activity on a limited number of strains. Inquest to determine the antimicrobial spectrum and real potential of PEO as an antimicrobial using data on 4598 bacteria and 67 fungi of 74 genera isolated from clinical infections and associated environment, this analytical study was conducted. Almost 3/4th of isolates tested were resistant PEO. The PEO had poor antimicrobial activity against most the common groups of pathogenic bacteria. However, PEO was active against most of the Aggregatibacter, Acinetobacter, Actinomyces, Moraxella, Dermatophilus and Staphylococcus species strains often associated with topical infections. Antimicrobial activity of PEO was significantly (p, <0.01) better against oxidase and Gram-positive (O+G+) bacteria than against O-G- bacteria. The MIC of PEO varied greatly from one part million (ppm) to more than 10000 ppm for members of the different species of bacteria. The study indicated that the potential of PEO can be explored further for developing an alternative antimicrobial therapy against topical infections.

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Published

2019-08-01

How to Cite

Bhoj Raj Singh, Dharmendra Kumar Sinha, Vinodh Kumar O.R, Abhijit M. Pawde, Ujjwal Kumar D.E, & Vinod Kumar Gupta. (2019). Comparative antimicrobial activity of pogostemon cablin (patchouli) essential oil (PEO) and conventional antimicrobials against clinically important microbes. World Journal of Pharmaceutical Sciences, 7(8), 47–65. Retrieved from https://wjpsonline.com/index.php/wjps/article/view/antimicrobial-activity-pogostemon-cablin

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Section

Research Article

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