Antimicrobial study of the optimized floating microspheres of cefixime

Abstract

Floating microspheres of cefixime were prepared by ionotropic gelation method. The method was optimized by 3² full factorial experimental designs. Antimicrobial activity of the formulation was evaluated by cup plate method in Muller Hinton Agar (MHA) medium. The microorganisms were inoculated aseptically by pour plate method. The zone of inhibition of the formulation was measured and compared with pure drug and the results were statistically evaluated. The results showed that the drug released from the formulation was effectively inhibiting the growth of microorganisms at concentrations of 125µg/ml and 250µg/ml. The floating microspheres of cefixime trihydrate show promising results in antimicrobial studies.