Antioxidant and Antiarthritic Activity of Plant Rivea Hypocrateformis by in-vitro Methods

Shanthini Nachiar G; Pallavi Pal; Mayuri Mishra

Authors

Shanthini Nachiar G Department of Pharmacognosy, C L Baid Metha College of Pharmacy, Chennai, Tamil Nadu, India
Pallavi Pal Department of Pharmaceutics, Pranveer Singh Institute of Technology, Kanpur, Uttar Pradesh, India
Mayuri Mishra Department of Pharmacology, Pranveer Singh Institute of Technology, Kanpur, Uttar Pradesh, India

Keywords:

Rivea hypocrateriformis, Antioxidant, Anti-arthritic activity, 2, 2-diphenyl-1-picrylhydrazyl (DPPH), Ethanolic extract of Rivea hypocrateriformis (EERH)

Abstract

Rivea hypocrateriformis is herb, which is traditionally used to cure various diseases. It contains flavonoids, tannins and phenolic compounds, which act as anti-inflammatory, antioxidant, anticancer, antiviral and antibacterial activities. Hence, the present study was undertaken with the objective of evaluating the anti-arthritic activity and antioxidant property of extract of Rivea hypocrateriformis. Extract of Rivea hypocrateriformis was prepared and analyse the antioxidant and antiarthritic activity by in-vitro model. The results obtained from DDPH method has been observed, IC50 of EERH was found TO be 71.25µg/ml, this study showed that the extract has a significant free radical scavenging activity. According to hydrogen peroxide scavenging method IC50 of EERH was 112.79µg/ml. Since phenolic compounds present in the plant extract are good electron donor, they may accelerate the conversion of hydrogen peroxide to water. It has been reported that the inhibition of protein denaturation by EERH was may be due to the presence of Flavanoids and tannins. The EERH showed 98.71% inhibition.