Antiplasmodial, anti-inflammatory and DPPH scavenging activities of extracts of the stem barks of Discoglypremna caloneura (Pax) Prain

Paul Djouonzo Toukam; Lauve Rachel Tchokouaha Yamthe; Alembert Tiabou Tchinda; Fabrice Fekam Boyom; Joseph Tanyi Mbafor

Antiplasmodial, anti-inflammatory and DPPH scavenging activities of extracts of the stem barks of Discoglypremna caloneura (Pax) Prain

Authors

Paul Djouonzo Toukam Department of Organic Chemistry, Faculty of Science, University of Yaounde I, P.O. Box 812, Yaoundé, Cameroon
Lauve Rachel Tchokouaha Yamthe Institute of Medical Research and Medicinal Plant Studies, P.O. Box 13033, Yaoundé, Cameroon
Alembert Tiabou Tchinda Institute of Medical Research and Medicinal Plant Studies, P.O. Box 13033, Yaoundé, Cameroon
Fabrice Fekam Boyom Laboratory for Phytobiochemistry and Medicinal Plants Studies, Faculty of Science, University of Yaoundé I, P.O. Box 812, Yaoundé, Cameroon
Joseph Tanyi Mbafor Department of Organic Chemistry, Faculty of Science, University of Yaounde I, P.O. Box 812, Yaoundé, Cameroon

Keywords:

Discoglypremna caloneura, Plasmodium falciparum, antiplasmodial, DPPH scavenging, denaturation, isolation

Abstract

In this study, the stem bark of Discoglypremna caloneura was subjected to phytochemical study and biological activity screenings. The hexane and ethyl acetate extracts exhibited significant inhibitory activities on strain W2 of Plasmodium falciparum with IC50 values 4.78 and 4.6 μg/ml respectively. None of the extracts was toxic to erythrocytes at concentrations up to 10 μg/mL. In the anti-inflammatory test, negligible inhibition of serum bovine albumin denaturation was observed for all extracts. The DPPH scavenging activity, although also insignificant was limited to ethyl acetate and methanol extracts, the hexane extract showed no activity. Tricosanoic acid, 3-O-acetylaleuritolic acid and a mixture of β-sitosterol and stigmasterol were isolated from the hexane extract.

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Published

2017-05-27

How to Cite

Paul Djouonzo Toukam, Lauve Rachel Tchokouaha Yamthe, Alembert Tiabou Tchinda, Fabrice Fekam Boyom, & Joseph Tanyi Mbafor. (2017). Antiplasmodial, anti-inflammatory and DPPH scavenging activities of extracts of the stem barks of Discoglypremna caloneura (Pax) Prain. World Journal of Pharmaceutical Sciences, 5(6), 235–239. Retrieved from https://wjpsonline.com/index.php/wjps/article/view/antiplasmodial-anti-inflammatory-discoglypremna-caloneura