Caffeine Consumption Protects Against High Fat Diet-Induced Hepatic steatosis

Abstract

Nonalcoholic fatty liver disease (NAFLD) is one of the most common liver diseases and is a part of the metabolic syndrome. Currently, there are interventions that used to treat risk factors associated with NAFLD. Caffeine treatment exerted hepatoprotective, antioxidant effect and limit the hepatocellular injury. This study examined whether caffeine can ameliorate liver injury induced by high fat diet (HFD) feeding. Three groups of rats were used and treated for 16 weeks as follow: CTRL group, rats were fed a standard diet; HFD group, rats were fed HDF; and Caffeine 10 group, rats were fed HDF for 16 week in addition to caffeine (10 mg/kg) for last 8 weeks. The HFD-induced liver injury is determined biochemically and by histopathological examination. Results showed that caffeine treatment significantly decreased the elevated serum ALT, AST. Furthermore, caffeine reduced lipid profile biomarkers. In conclusion, this study revealed that caffeine treatment exerted hepatoprotective, fostering lipid metabolism and limit the hepatocellular injury induced by HFD.