Cefixime trihydrate loaded chitosan-alginate transdermal patches

Abstract

Cefixime trihydrate is a third generation cephalosporin with a broad spectrum bactericidal activity. Due to its short biological half-life, it’s required for frequent dosing, poor bioavailability and first pass metabolism. Transdermal matrix patches of Cefixime trihydrate were prepared by Solvent casting method using cross linked polymers with Chitosan and Sodium alginate with or without permeation enhancer and the patches were evaluated and found to be having good physicochemical properties. The cumulative percentage of drug permeation without and with permeation enhancer after 24 h through rat skin was found to be FS-1 to FS-4 was found 49.40% to 50.84% and FPE-1 to FPE-4 was found 75.48 % to 88.38 %. The kinetic profile show that the drug release followed zero-order kinetics and well fits with Higuchi’s model and followed by non-fickian diffusion mechanism of drug release. The drug permeation rate (flux) and enhancement ratio was found to be maximum in the formulation FPE-2. Further, selected for invivo study of FPE-2 formulation and compared with oral suspension by using the rats, the results shows after 24 h 82.91% and 28.04%. The invitro-invivo correlation of FPE-2 was found to be 0.969, which indicates that linear and super-imposable.