Cranberry Extract Enhance Antioxidant Potential in Ehrlich’s Ascites Carcinoma–Bearing Female Albino Mice

Abstract

The present study was to evaluate anti-cancer effects of cranberry extract (75 and 150mg/kg.b.w), 5-Flourourasil (20mg/kg b.w. i.p) and their combinatorial formulation in female mice induced by Ehrlich ascites cells for 21 consecutive days prior. Ten days after intraperitoneal inoculation of tumor EAC cells in mice, cranberry extract was administrated at (75 and 150mg/kg.b.w) daily for 21 consecutive days. On the 22^th day, the mice were sacrificed for the estimation of tumor growth (tumor volume), and biochemical parameters (glucose, insulin, 17β-estradiol, progesterone and follicular stimulating hormone (FSH)  alanine transaminase (ALT), aspartate transaminase (AST), alkaline phosphatase (ALP), lactate dehydrogenase (LDH), lipid peroxides (TBARS), reduced glutathione (GSH), superoxide dismutase (SOD), catalase  (CAT), total cholesterol (TC), triglycerides (TG), HDL-C, LDL-C, nitric oxide (NO) and tumor necroses factor-α (TNF-α). The results of this study also showed that administration of cranberry extract, 5-Flourourasil both individually and in combination for 21 days to the carcinoma induced mice demonstrated a significant (P<0.01) decrease in tumor volume and a significant (P<0.01) improvement in biochemical parameters and life span as compared to the EAC control mice than either agent alone. On the other hand, the results clearly suggest that the combination of cranberry extract and 5-Flourourasil produced higher antioxidant activities on experimental EAC control as well as 5-Flourourasil mice than their individual influences.