Role of cytokine in Pathogenesis of Streptococcus agalactiae in placentitis of aborted women

Abstract

S. agalactiae has been appearing as a vital human pathogen and a gradually important cause of aggressive infections in immunocompromised adults and older, the aim of the study was to find out if placental infection with S. agalactiae influenced the levels of interleukin 2 (IL-2) in aborted women. A total of 100 aborted women aged between (16 - 42) years, were involved in this study. Placentas specimens were cultured to isolate the Streptococcus agalactiae, the level of cytokine in the serum was measured by commercial ELISA tests. Our results showed that there are 21 streptococcal isolates from Placentas specimens, Specific isolation and identification were done for S. agalactiae. Out of the 7 S. agalactiae isolates, significant difference could be found in serum levels of IL-2 (P≤ 0.05) between these two investigated groups (infected and uninfected with S. agalactiae).