Design, development and evaluation of pulsatile drug delivery system using tablet in tablet formulation

Authors

  • Swati Mittal Vivekanand Education Society’s College of Pharmacy, Hashu Advani Memorial Complex, Behind Collector Colony, Chembur (E), Mumbai - 400 074
  • Kawale Sandip Vivekanand Education Society’s College of Pharmacy, Hashu Advani Memorial Complex, Behind Collector Colony, Chembur (E), Mumbai - 400 074
  • John Jobin Vivekanand Education Society’s College of Pharmacy, Hashu Advani Memorial Complex, Behind Collector Colony, Chembur (E), Mumbai - 400 074

Keywords:

Aceclofenac, hydroxylpropyl cellulose (HPC), lag time, press coated tablet

Abstract

Tablet in tablet formulation, containing Aceclofenac (API) in core tablet and coated with hydroxylpropyl cellulose (HPC) was evaluated for time drug release with predetermined lag time and subsequent rapid release phase. Various types of press coated tablets were prepared using single punch tablet machine. They were evaluated for various physicochemical properties and in vitro dissolution study was carried out by USP type II (paddle) apparatus. Initially, drug release was slow for 3-6 hr followed by a burst release. Lag time of tablet increased with increasing viscosity of the HPC and load of outer shell. However, the compression load had little effect.

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Published

2014-11-01

How to Cite

Swati Mittal, Kawale Sandip, & John Jobin. (2014). Design, development and evaluation of pulsatile drug delivery system using tablet in tablet formulation. World Journal of Pharmaceutical Sciences, 2(11), 1499–1505. Retrieved from https://wjpsonline.com/index.php/wjps/article/view/design-evaluation-pulsatile-dds-tablet-formulation

Issue

World J Pharm Sci 2014; 2(11): 1416-1591

Section

Research Article

License

Creative Commons License

This work is licensed under a Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International License.