Design, synthesis, characterization and anticancer activities of novel 3-(4-tert-butyl benzyl) [1,2,4] triazolo[3,4-a] phthalazine derivatives

Ningaraddi S. Belavagi; Narahari Deshapande; Manjunath G. Sunagar; Supreet Gaonkar; Imtiyaz Ahmed M. Khazi

Design, synthesis, characterization and anticancer activities of novel 3-(4-tert-butyl benzyl) [1,2,4] triazolo[3,4-a] phthalazine derivatives

Authors

Ningaraddi S. Belavagi Depatment of Chemistry, Karnatak University, Dharwad, Karnataka, India
Narahari Deshapande Depatment of Chemistry, Karnatak University, Dharwad, Karnataka, India
Manjunath G. Sunagar Depatment of Chemistry, Karnatak University, Dharwad, Karnataka, India
Supreet Gaonkar Depatment of Chemistry, Karnatak University, Dharwad, Karnataka, India
Imtiyaz Ahmed M. Khazi Depatment of Chemistry, Karnatak University, Dharwad, Karnataka, India

Keywords:

Triazolophthalazine, Cytotoxic activity, Suzuki reaction, Boronic acids

Abstract

A novel series of 6-aryl substituted 3-(4-tert-butylbenzyl)[1,2,4]triazolo[3,4-a]phthalazines(6a-g) have been synthesized and characterized by spectral analysis and evaluated for their in-vitro cytotoxicity against a panel of five human cancer cell lines by MTT method. Results showed that these compounds selectively induced cell viability towards human breast cancer lines over the other cancer cell lines tested and compound 6g exhibited good anticancer activities compared to 5-fluorouracil (standard used) against MCF-7 (Breast) cell lines with IC₅₀ value 16.5 ± 0.4µM.

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Published

2014-12-01

How to Cite

Ningaraddi S. Belavagi, Narahari Deshapande, Manjunath G. Sunagar, Supreet Gaonkar, & Imtiyaz Ahmed M. Khazi. (2014). Design, synthesis, characterization and anticancer activities of novel 3-(4-tert-butyl benzyl) [1,2,4] triazolo[3,4-a] phthalazine derivatives. World Journal of Pharmaceutical Sciences, 2(12), 1746–1752. Retrieved from https://wjpsonline.com/index.php/wjps/article/view/design-synthesis-anticancer-phthalazine-derivatives