Effect of Ocimum sanctum Linn (Tulsi) leaves on pyrexia

Abstract

Background: Drug therapy of fever with Standard drugs, are always accompanied by side effects which is a well-known factor and the therapy is open to other alternative/adjuvant supplements/ medications with no/minimal side effects. Our traditional “holy herb” Tulsi are   indicated for all reasons and in all the seasons. In view of this, a trial was conducted for their antipyretic activity. Objective: To assess the anti-pyretic property of Ocimum Sanctum Linn fresh (tulsi) leaves, (native) preparation, in experimentally induced acute fever in   animal models. Methodology: Adult Wistar Albino Rats of both sex weighing 125-150gms were randomly divided into 2 groups (n=6); First group were the control subjects (distilled water), and the second were the test group (fresh Tulsi leaves (400mg/kg). After recording the basal temperature, fever was induced by injecting 15% of brewer’s yeast. 18 hrs after giving injection, each rat was fed orally with vehicle and test drug accordingly. Temperature was recorded to all animals at every 30, 60,120 and 180 minutes respectively. Results: There was a significant reduction of fever in Tulsi group whereas the temperature control was not significant statistically in control group. Conclusion: Tulsi may be used as primary drug in the therapy of fever.