Formulation and invitro evaluation of captopril floating microspheres
https://doi.org/10.54037/WJPS.2022.100902
Keywords:
Captopril; ACE Inhibitor; Renovascular HypertensionAbstract
Captopril is an ACE inhibitor used for the management of essential or renovascular hypertension. The present work is formulation of captopril floating microspheres by using xanthan gum, guar gum and karaya gum. All the formulations were subjected for preformulation evaluation. Results of preformulation studies, FTIR, SEM, particle size and size distribution, % yield, drug content, buoyancy time, entrapment efficiency, in vitro dissolution and release kinetics. The FTIR Spectra revealed that, there was no interaction between polymers and Captopril. On the basis of release data of Captopril formulation F6 showed a good controlled release profile with maximum entrapment efficiency because of optimum drug polymer concentration i.e., 1:1:1 ratio (guar gum+ xanthum gum) with sodium alginate than other drug: polymer ratios. The invitro dissolution data for best formulation F6 were fitted in different kinetic models i.e, zero order, first order, Higuchi and korsemeyerpeppas equation. Optimized formulation F6 shows zero order drug release with Super case II transport mechanism.
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