Comparative study of formulations of ondansetron hydrochloride orodispersible tablets by effervescent and sublimation methods

Authors

  • Shrawani Lamichhane National Model College for Advance Learning, Tribhuvan University, Nepal
  • Pradeep Paudel National Model College for Advance Learning, Tribhuvan University, Nepal
  • Aastha Shrestha National Model College for Advance Learning, Tribhuvan University, Nepal
  • Srijan Shrestha National Model College for Advance Learning, Tribhuvan University, Nepal
  • Junu Khatri Silwal National Model College for Advance Learning, Tribhuvan University, Nepal
  • Bhupendra Kumar Poudel National Model College for Advance Learning, Tribhuvan University, Nepal

Keywords:

Orodispersible tablet, Ondansetron hydrochloride, crospovidone, citric acid, sodium bicarbonate, camphor

Abstract

In the present work orodispersible tablets of Ondansetron hydrochloride were formulated by effervescent and sublimation method using factorial design. In the effervescent method, crospovidone (1.31%-4.68%) was used as superdisintegrant whereas citric acid (7.95%-18.04%) and sodium bicarbonate (5.22%-28.77%) were used as effervescent agent. In the sublimation method, crospovidone (1.58%-4.41%) was used as superdisintegrant whereas camphor (6.34%-17.35%) was used as subliming agent. The prepared batches of tablets were evaluated for hardness, friability, drug content uniformity, wetting time, disintegration time and In Vitro drug release pattern. Total 15 batches were formulated by effervescent method and 9 batches were formulated by sublimation method. Disintegration time of the formulations prepared by effervescent method was found between 13-36 secs whereas formulations prepared by sublimation method showed disintegration time between 7-39 secs. Among all the formulations, the formulation (S6) prepared by sublimation method using crospovidone 4% and camphor 8% was found to have the minimum disintegration time (7 seconds). Finally, it was concluded that Orodispersible tablet of Ondansetron Hydrochloride can be successfully formulated using effervescent and sublimation method and can be used as a novel drug dosage form for pediatric and geriatric with improved patient compliance and enhanced bioavailability.

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Published

2014-10-01

How to Cite

Shrawani Lamichhane, Pradeep Paudel, Aastha Shrestha, Srijan Shrestha, Junu Khatri Silwal, & Bhupendra Kumar Poudel. (2014). Comparative study of formulations of ondansetron hydrochloride orodispersible tablets by effervescent and sublimation methods. World Journal of Pharmaceutical Sciences, 2(10), 1323–1338. Retrieved from https://wjpsonline.com/index.php/wjps/article/view/formulations-ondansetron-orodispersible-tablets

Issue

Section

Research Article