Optimization as an effective tool in pharmaceutical development: A review
Keywords:Optimization, Variables, Design of experiment, Factorial design, Randomized design, Systematic approach
Pharmaceutical industry is industry of complex processes and procedures. Development of a new dosage form in formulation and development takes a lot of efforts, the effect of various process variables and different parameters involved in the process. It becomes very difficult to study the process outputs while performing the process, so there is a need to understand the process variables initially at the start of the process and keep an eye on those parameters affecting the outputs throughout the process. Optimization is defined as, to make as functional, perfect, as effective as possible. It is used in formulation and processing, to find the best way of analyzing the effect of process variables, their influence on process and process outputs. Optimization is process of finding the best way of using the existing resources while considering of all factors that influence decisions in any experiment. Optimization technique provides both an ability to explore and depth of understanding and define ranges for formulation and processing factors. Optimization technique is a beneficial tool to quantitate a formulation that has been qualitatively determined. The current review tries to enlighten the potential use and application of optimization technique as an effective tool in designing pharmaceutical dosage form.
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