Osmotic drug delivery systems: A review

Abstract

Oral route is most predominant route for administration of drugs. Recent Novel drug delivery systems are developed in oral route to improve the patient compliance and reduce adverse effects. Osmotic controlled drug delivery systems are a type of Novel drug delivery systems which utilize osmotic pressure for controlled delivery of active agent(s). The release of drug(s) from osmotic systems is independent of gastric pH & gastric motility. The release of drug(s) from osmotic systems is affected by various formulation factors such as osmotic pressure of the core component(s), solubility and size of the delivery orifice, and nature of semi permeable membrane. Different types of osmotic systems have been developed implantable & oral. This review focuses on types of Osmotic drug delivery systems, factors affecting release of drug and available drugs in market.