PHYTOCHEMICAL AND PHARMACOLOGICAL EVALUATION OF HEDYCHIUM CORONARIUM J. KOENING FOR ANTIUROLITHIATIC ACTIVITY

Abstract

Kidney stones formation or Urolithiasis is a complex process that results from series of several physicochemical events including super – saturation, nucleation, growth, aggregation and retention within the kidneys.  Among the treatments include extracorporeal shock wave Lithotripsy (ESWL) and drug treatment. Even this ESWL treatment may cause acute renal injury, decrease in renal function and increase in stone recurrence. Data from in-vitro trails reveal that phytotherapeutic agents could be useful as either could be useful as either alternative or an adjunct therapy in the management of Urolithiasis. In the indigenous system of medicine, roots of Hedychium coronarium J. Koening are reported to be useful in the treatment of urinary stones. Hence, in the present study, the roots of Hedychium coronarium J. Koening have been selected for antiurolithiatic activity on experimental kidney stones. (In-vitro activity) Hedychium coronarium J. Koening is one of the ingredients of reputed herbal formulation Cystone for the treatment of kidney stones. In this study Alcoholic extract & Aqueous extract of roots part of the plant were evaluated for their potential to dissolved experimentally prepared kidney stones calcium oxalates, by an In-vitro model. Alcoholic extracts obtained from roots part demonstrated highest dissolution of Calcium oxalate (Kidney Stones) when compared to test extracts at 10 mg concentration. Reference standard formulation Cystone was found to be equally effective (39.12%) when compared to alcoholic extract of roots part.