A review on nanoneedle- A smart nanovector for drug delivery

Abstract

Nanotechnology has become one of the important applicant in biology through the provision of latest nanotechnology tools to probe and manipulate biological processes at the nanoscale (~1 to100 nm), which is the length scale where many fundamental biological processes occur. One-dimensional nanomaterial, such as nanotubes and nanowires, have been used as intracellular biosensors, delivery carriers, and imaging agents. The nanoneedle-based drug delivery provides new possibilities for efficient, specific, and precise introduction of biomolecules into living cells for high-resolution studies of biological processes and it has potential application in solving broad biological complications. The delivery of biomolecules into living cells could provide by a nanoneedle-based delivery system with high spatiotemporal resolution, minimal intrusion and damage. The nanoneedles can act as a carrier for cargo molecules such as peptides, protein, nucleic acids, and drugs. This review provide insight into all nanostructured materials (NSM) and major emphasis set on nanoneedles as a nascent drug delivery vehicle and as a probe to manipulate cellular processes.