Effect of sodium alginate concentration on characteristic, viability, and antibacterial activity of probiotic-alginate microparticles

Authors

  • Tutiek Purwanti Faculty of Pharmacy, Airlangga University (Unair), Surabaya, Indonesia
  • Dewi Melani Hariyadi Faculty of Pharmacy, Airlangga University (Unair), Surabaya, Indonesia

Keywords:

Lactobacillus acidophillus,microparticles, sodium alginate, extrusion, antibacterial activity

Abstract

Probiotic (Lactobacillus acidophilus) has been known as an effective antibacterial activity, however  storage, high oxygen levels, and gastric acid condition was generally decrease the probiotic viability. To maintain the probiotics’ viability, extrusion technique was selected to produce microparticles. This technique used sodium alginate polymer and calcium chloride cross linking solution. This research investigated effect of sodium alginate concentration on the physical characteristics, viability and antibacterial activity. Results showed that increasing alginate concentration from 2.5% to 3.5% increased microparticle size (from 15.40µm to 37.53µm). Viability of Lactobacillus acidophillus of all formulas were above 94%, however an increased of alginate concentration did not significantly affect antibacterial activity. The extrusion method demonstrated its potential in encapsulation of Lactobacillus acidophillus for probiotics delivery.

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Published

2015-03-05

How to Cite

Tutiek Purwanti, & Dewi Melani Hariyadi. (2015). Effect of sodium alginate concentration on characteristic, viability, and antibacterial activity of probiotic-alginate microparticles. World Journal of Pharmaceutical Sciences, 3(3), 426–429. Retrieved from https://wjpsonline.com/index.php/wjps/article/view/sodium-alginate-antibacterial-probiotic-alginate-microparticles

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Section

Research Article