Solubility Enhancement of Glybenclamide by Solid Dispersion

Abstract

Glibenclamide is a highly lipophilic drug therefore it faces challenges in solubility and absorption patterns. This study aims to improve the solubility and dissolution characteristics of Glibenclamide by preparing solid dispersion using solvent evaporation technique and to study the effect of particle size and different dissolution media on drug release property. The carrier used was Soluplus as a solubilizer. The solid dispersions were prepared in drug: carrier ratios 1:0.5, 1:1, 1:2 1:3, 1:4, 1:6 and 1:8 by solvent evaporation method. The resultant solid dispersions were evaluated for solubility studies at different pH conditions. The release rate of drug from the capsule formulation was studied. Solid state characterization of solid dispersion has been carried out by DSC, FTIR. Solid dispersions were subjected to accelerated stability studies and were characterized by DSC. Our results describe an effective solid dispersion of glibenclamide with improved solubility and dissolution which results in the improved bioavailability.