Comparative study of different solubility enhancement techniques on dissolution rate of zaltoprofen

Abstract

The aim of present work to prepare solid dispersion of zaltoprofen, a water insoluble drug, with β-cyclodextrin in order to improve the solubility and dissolution rate of drug. The solid dispersions of zaltoprofen-β-CD prepared by different methods were characterized by Differential Scanning calorimetry (DSC), Powder X-ray Diffraction (XRD), Fourier-transform infrared spectroscopy, solubility and dissolution studies. Identification of polymorphism done by X-ray diffraction and for thermo dynamic properties using DSC. The solubility of all the solid dispersions showed improvement compare to pure drug. The drug release profile was carried out in phosphate buffer 6.8 pH using USP type II paddle dissolution apparatus. From the studies, it was found that the kneading method shows the better enhancement of dissolution in compare to physical mixture, solvent evaporation, fusion method and microwave induced radiation.