A study on association of H. pylori in patients with dyspepsia of any cause in a tertiary private hospital

Abstract

The study of gastric bacteriology has gained significant impetus since the isolation of H.pylori from gastric mucosal biopsies in 1983 by Barry Marshall and Robin Warren in Perth (Australia). They are able to demonstrate a strong association between the presence of H.pylori and the finding of inflammation on gastric biopsy. To investigate the association of H.pylori in patients with dyspepsia of any cause i.e., in the form of gastric ulcer, duodenal ulcer, gastritis, carcinoma stomach and non-ulcer dyspepsia with the help of following parameters- Direct biopsy urease test, Gram stained biopsy smear examination, Culture, Histopathological examination. This study was under taken at the Department of surgery, Narayana medical college, Nellore from January 2007 to July 2008. A total of 150 patients with duodenal ulcers, gastric ulcers, antral gastritis, gastric carcinoma and dyspepsia of any kind were studied. Evidence for H.pylori infection as decided by the laboratory tests gradually increased from 21 years to 50 years and showed decline thereafter. Incidence is more in males than females.