Synthesis of 4H-pyrido [1,2-a]pyrimidin-4-one derivatives as Anti-inflammatory agents

Gangadhar Meti; Pramod Kattimani; Ravindra Kamble; H. C. Devarajegowda; Mahadev Kumbar; D. Jagadeesh Prasad

Synthesis of 4H-pyrido [1,2-a]pyrimidin-4-one derivatives as Anti-inflammatory agents

Authors

Gangadhar Meti Department of Studies in Chemistry, Karnataka University, Pavate Nagar, Dharwad- 580 003, India
Pramod Kattimani Department of Studies in Chemistry, Karnataka University, Pavate Nagar, Dharwad- 580 003, India
Ravindra Kamble Department of Studies in Chemistry, Karnataka University, Pavate Nagar, Dharwad- 580 003, India
H. C. Devarajegowda Department of Physics, Yuvaraja’s College, University of Mysore, Mysore – 590 005, India
Mahadev Kumbar Department of Studies in Chemistry, Karnataka University, Pavate Nagar, Dharwad- 580 003, India
D. Jagadeesh Prasad Department of Studies in Chemistry, Mangalore University, Konaje – 574 199, India

Keywords:

Hyaluronidase, Pyrido[1,2-a]pyrimidin-4-one, OSIRIS property explorer, Anti-inflammatory activity

Abstract

We have developed 4H-pyrido[1,2-a]pyrimidin-4-one derivatives appended to various nitrogen containing heterocycles (3a-f). The structures of newly synthesized compounds were confirmed by spectral as well as analytical techniques and single crystal X-ray analysis of compound 4b is carried out. Further, the results of Osiris property explorer analysis and in vitro testing for the anti-inflammatory activity against hyaluronidase enzyme of these compounds are presented. Compounds 4e and 5f possessing N-methylpiperazine and piperazine ethoxy ethanol ring respectively have shown more growth inhibition than the standard drug Indomethacin at 10 μg concentration

Downloads

PDF Download PDF Abstract

Published

2015-02-04

How to Cite

Gangadhar Meti, Pramod Kattimani, Ravindra Kamble, H. C. Devarajegowda, Mahadev Kumbar, & D. Jagadeesh Prasad. (2015). Synthesis of 4H-pyrido [1,2-a]pyrimidin-4-one derivatives as Anti-inflammatory agents. World Journal of Pharmaceutical Sciences, 3(2), 277–287. Retrieved from https://wjpsonline.com/index.php/wjps/article/view/synthesis-4h-pyrido-pyrimidin-4-one-anti-inflammatory-agents