Synthesis, antioxidant activity and QSAR studies of some pyridine derivatives

Ludmila S. Bobkova; Andrew R. Khairulin; Anatoly M. Demchenko; Tatiana A. Bukhtiarova

Synthesis, antioxidant activity and QSAR studies of some pyridine derivatives

Authors

Ludmila S. Bobkova Department of the synthesis of biologically active substances, SI “Institute of pharmacology and toxicology NAMS of Ukraine”, Kiev, Ukraine
Andrew R. Khairulin Department of the synthesis of biologically active substances, SI “Institute of pharmacology and toxicology NAMS of Ukraine”, Kiev, Ukraine
Anatoly M. Demchenko Department of the synthesis of biologically active substances, SI “Institute of pharmacology and toxicology NAMS of Ukraine”, Kiev, Ukraine
Tatiana A. Bukhtiarova Department of the synthesis of biologically active substances, SI “Institute of pharmacology and toxicology NAMS of Ukraine”, Kiev, Ukraine

Keywords:

pyridine derivative, antioxidant activity, reactivation ability, QSAR studies

Abstract

New quaternary pyridine salts and bases was synthesized and characterized in the presence of iminomethyl-fragment containing the hydroxyl group or the hydroxy-ethyl group or the hydroxyphenyl group with imine nitrogen atom. The synthesized compounds were tested in vitro for an antioxidant activity with a stable radical 2.2-diphenyl-1-picrylhydrazyl and reactivation ability of Sarin-inhibited AChE. The influence of antioxidant activity parameters on reactivation ability and toxicity of the studied compounds was analyzed.

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Published

2015-05-03

How to Cite

Ludmila S. Bobkova, Andrew R. Khairulin, Anatoly M. Demchenko, & Tatiana A. Bukhtiarova. (2015). Synthesis, antioxidant activity and QSAR studies of some pyridine derivatives. World Journal of Pharmaceutical Sciences, 3(5), 800–809. Retrieved from https://wjpsonline.com/index.php/wjps/article/view/synthesis-antioxidant-activity-qsar-studies-pyridine-derivatives