Synthesis and pharmacological study of substituted amino-N-(4-oxo-2-phenyl-1,3-thiazolidin-3-yl)acetamides

Abstract

Ulcers are not usually life threatening, however they can cause serious damage which may leads to cancer if untreated. In the present study with the intension of enhancing the array of therapeutic ammonites to treat ulcer a series of thiazolidinone derivatives (4a-4f) were synthesized from substituted Schiff bases with thioglycolic acid in presence of anhydrous zinc chloride. The structures of these synthesized compounds have been characterized on the basis of physical constants, spectral data and evaluated them for their possible antiulcer activity using ethanol induced gastric lesion model. All the compounds studied showed significant antiulcer activity against ethanol induced gastric ulcers. Lansoprazole was used as a standard drug for comparison and the Compound 4f protected animals from ethanol induced ulcers at the dose of 300 mg/kg, which is comparable to that of standard drug lansoprazole (300 mg/kg).