Evaluation of therapeutic potential of Withania somnifera root powder on oxidative stress and cartilage damage in collagen induced arthritis in rats

Abstract

Withania somnifera, commonly known as Ashwagandha, is a well-known herb in the field of alternative medicines. Its anti-inflammatory and immunomodulatory potentials have been authenticated well. The root powder of W. somnifera (600 and 800 mg/kg) was evaluated for its anti-oxidative and anti-cartilage damage potential in collagen induced arthritic (CIA) rats, using methotrexate (0.3 mg/kg) as a standard drug. Changes in biochemical and histopathological parameters in response to W. somnifera root powder were determined to assess its effect on CIA rats. W. somnifera root powder at 600 mg/kg resulted in a significant reduction in oxidative stress and cartilage damage and showed anti-oxidative and anti-cartilage damage potential in experimental CIA rat model.