Correlation of spot urine protein creatinine ratio with twenty four urine protein and serum lipid profile in type 2 diabetic nephropathy patients

Abstract

The present study aimed to analyze the association between proteinuria as measured by 24 urine protein and urine protein creatinine ratio, and lipid variables in diabetic patients with or without nephropathy. The study subjects were sixty four diabetic patients with nephropathy and fourty seven diabetic patients without complications. Levels of triglycerides, total cholesterol, LDL cholesterol, and HDL cholesterol were estimated in serum samples. In 24 hour urine samples, total protein was estimated, and in spot urine samples, levels of creatinine and protein were estimated. Diabetic nephropathic patients showed significantly higher serum levels of triglycerides and significantly lower serum level of HDL cholesterol, in comparison to diabetic patients without complications. The total cholesterol and LDL cholesterol levels did not differ between the two groups. Urinay protein excretion (24 hours) and urine protein creatinine ratio were significantly       higher     in patients with diabetic nephropathy than the              diabetic without complications. Urinary protein: creatinine ratio showed significant positive correlation with 24 hr urine protein and serum triglycerides, and negative correlation with serum HDL cholesterol, in diabetic nephropathic patients. Urine protein creatinine ratio had sensitivity of 100%, specificity of 90.90%, and positive prediction rate of 91.67% to diagnose diabetic nephropathy. Future studies with larger sample size correlating urine protein: creatinine ratio with clinical staging of nephropathy, and analyzing its value in prognosis and follow up of treatment, are required.