A complete profile on Xylocarpus moluccensis: traditional uses, pharmacological activities and phytoconstituents

Abstract

The present work offers a review addressing the ethnomedical, active constituents and pharmacological activity of Xylocarpus moluccensis (belonging to Meliaceae family) regarded as one of the most significant plant species in traditional system of medicine. The plant is used in  different parts of the world for the treatment of several ailments like diarrhea, fever, dysentery, candidacies, scabies, baby rash, stomach pains, and constipation joint pains, chest pains, and relapsing sickness etc., Xylocarpus moluccensis is the source of a diverse kind of chemical  constituents such as swietemahonolide, febrifugin, khayasin T, febrifugin A, gedunin, isolariciresinol, phaseic acid, aromadendrin, 4-hydroxy cinnamic acid, 4-hydroxybenzoic acid, 4-hydroxyphenylaceticacid, and xylogranatinin. The isolated phytochemicals as well as different extracts exhibited significant biological activities such as antibacterial, anti diabetic, antioxidant activity, antifilarial, anti diarrheal, CNS depressant and cytotoxic activities. Exhaustive research regarding isolation of more phytochemicals and pharmacology study on this medicinal plant is still necessary so as to explore the plant regarding its medicinal importance. Therefore, the aim of this review is to boost up present day researchers in this direction to undertake further investigations of this plant.