Antibacterial activity of methanol extract of Macaranga denticulata leaves and in silico PASS prediction for its six secondary metabolites

Authors

  • Abul Hasanat Department of Pharmacy, International Islamic University Chittagong, Bangladesh
  • Mohammad Shah Hafez Kabir Department of Pharmacy, International Islamic University Chittagong, Bangladesh
  • Mohammed Munawar Hossain Department of Pharmacy, International Islamic University Chittagong, Bangladesh
  • Mahmudul Hasan Department of Pharmacy, International Islamic University Chittagong, Bangladesh
  • Md. Abdullah Al Masum Department of Pharmacy, International Islamic University Chittagong, Bangladesh
  • Tanvir Ahmad Chowdhury Department of Pharmacy, International Islamic University Chittagong, Bangladesh
  • Didarul Islam Bhuiyan Department of Pharmacy, International Islamic University Chittagong, Bangladesh
  • Arafatul Mamur Department of Pharmacy, International Islamic University Chittagong, Bangladesh
  • Abu Sayeed Md. Golam Kibria Department of Pharmacy, International Islamic University Chittagong, Bangladesh

Keywords:

Macaranga denticulata, Gram-positive, Gram-negative, Zone of inhibition, PASS prediction

Abstract

Antibacterial properties of methanolic extract of Macaranga denticulata leaves was studied on three Gram positive and Four Gram negative bacteria by disc diffusion method. The extract showed zone of inhibition in highest concentration of 1000 µg/ml against Gram-positive bacteria Staphylococcus aureus (Nil), Bacillus subtilis (12mm), Bacillus cereus(Nil)and Gram-negative bacteria Salmonella typhi (15mm), Salmonella paratyphi (Nil), Escherichia coli (14mm), Pseudomonas aeruginosa (14mm). Six secondary metabolites of Macaranga denticulata namely 3-acetylaleuritolic acid, oleanolic acid, macarangin, scopoletin, β-sitosterol, stigmasterol were analyzed by the PASS for their different types of biological activities and found activities like hepatoprotectant, antiulcerative, antifungal, diuretic, insulin promoter, antinociceptive, anti-inflammatory, antihypercholesterolemic, anesthetic general, bone diseases treatment and vitamin.

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Published

2015-06-02

How to Cite

Abul Hasanat, Mohammad Shah Hafez Kabir, Mohammed Munawar Hossain, Mahmudul Hasan, Md. Abdullah Al Masum, Tanvir Ahmad Chowdhury, Didarul Islam Bhuiyan, Arafatul Mamur, & Abu Sayeed Md. Golam Kibria. (2015). Antibacterial activity of methanol extract of Macaranga denticulata leaves and in silico PASS prediction for its six secondary metabolites. World Journal of Pharmaceutical Sciences, 3(6), 1258–1266. Retrieved from https://wjpsonline.com/index.php/wjps/article/view/antibacterial-methanol-extract-macaranga-denticulata-leaves

Issue

Section

Research Article