Preparation and evaluation of raft forming systems of furosemide

Abstract

The aim of the present investigation is to prepare and evaluate raft forming systems of furosemide. Furosemide is a potent loop diuretic agent that comes under anthranilic acid derivative. Sodium alginate was used as the gelling agent, sodium bicarbonate and calcium carbonate were used as effervescent agents. For sustained release of drug, the polymers used were HPMC K15M, K100 and K200. The objectives are to sustain the drug release for 12 hours with floating characteristics of raft forming system. The results indicated that the raft strength, floating behaviour, drug release and other tableting characteristics of the optimized formulation are meeting the objectives.